The Arabidopsis epitranscriptome

Rupert G. Fray (Lead / Corresponding author), Gordon G. Simpson (Lead / Corresponding author)

Research output: Contribution to journalArticle

16 Citations (Scopus)
153 Downloads (Pure)

Abstract

The most prevalent internal modification of plant messenger RNAs, N<sup>6</sup>-methyladenosine (m<sup>6</sup>A), was first discovered in the 1970s, then largely forgotten. However, the impact of modifications to eukaryote mRNA, collectively known as the epitranscriptome, has recently attracted renewed attention. mRNA methylation is required for normal Arabidopsis development and the first methylation maps reveal that thousands of Arabidopsis mRNAs are methylated. Arabidopsis is likely to be a model of wide utility in understanding the biological impacts of the epitranscriptome. We review recent progress and look ahead with questions awaiting answers to reveal an entire layer of gene regulation that has until recently been overlooked.

Original languageEnglish
Pages (from-to)17-21
Number of pages5
JournalCurrent Opinion in Plant Biology
Volume27
Early online date3 Jun 2015
DOIs
Publication statusPublished - Oct 2015

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