The association between epithelial proliferation and disease progression in the oral mucosa

M. Macluskey, G. R. Ogden, M. Green, D. M. Chisholm, S. L. Schor, A. M. Schor

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    20 Citations (Scopus)

    Abstract

    The purpose of this study was to examine the possible association between epithelial proliferation and disease progression in the oral mucosa. Archival specimens of normal oral mucosa (n = 12), dysplasia (n = 17) and squamous cell carcinoma (n = 18) were sectioned and proliferating cells visualised by staining with Ki-67 antibody. The proliferative index of the epithelium (PI) was determined by total cell counts and point counting. Similar results were obtained using either method. Comparison of the three groups of tissues by one-way analysis of variance showed a significant increase in PI with increasing lesion severity (p <0.001). The PI of both dysplasia and carcinoma groups was significantly higher than that of normal oral mucosa (p <0.001). However, the difference between dysplasia and carcinoma groups was not significant. PI was not associated with tobacco or alcohol consumption. We therefore conclude that Ki-67 expression is an early marker of disease progression in the oral mucosa but, on its own, is not a good indicator of neoplastic transformation.
    Original languageEnglish
    Pages (from-to)409-14
    Number of pages6
    JournalOral Oncology
    Volume35
    Issue number4
    DOIs
    Publication statusPublished - Jul 1999

    Keywords

    • Proliferative index
    • Ki-67
    • Oral lesions
    • Normal mucosa
    • Dysplasia
    • Carcinoma
    • Tumour progression

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