The Association Between Tirzepatide Versus Insulin Glargine and NT-proBNP Levels in People With Type 2 Diabetes With or at Elevated Risk for Cardiovascular Disease: Post hoc Analyses of SURPASS 4

Naveed Sattar; Govinda J. Weerakkody; Darren K. Mcguire; Mikhail N. Kosiborod; Matthew M.Y. Lee; Paul Welsh; Ewan R. Pearson; Russell J. Wiese; Kevin Duffin; Jonathan Wilson; Noemi Pavo; Martin Hülsmann; Imre Pavo

doi:10.1161/CIRCULATIONAHA.124.072889

The Association Between Tirzepatide Versus Insulin Glargine and NT-proBNP Levels in People With Type 2 Diabetes With or at Elevated Risk for Cardiovascular Disease: Post hoc Analyses of SURPASS 4

Naveed Sattar (Lead / Corresponding author), Govinda J. Weerakkody, Darren K. Mcguire, Mikhail N. Kosiborod, Matthew M.Y. Lee, Paul Welsh, Ewan R. Pearson, Russell J. Wiese, Kevin Duffin, Jonathan Wilson, Noemi Pavo, Martin Hülsmann, Imre Pavo

Diabetes Endocrinology and Reproductive Biology

Research output: Contribution to journal › Letter › peer-review

Original language	English
Pages (from-to)	1430-1432
Number of pages	3
Journal	Circulation
Volume	151
Issue number	19
Early online date	12 May 2025
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.124.072889
Publication status	Published - 13 May 2025

Keywords

cardiovascular diseases
diabetes mellitus, type 2
heart failure
insulin glargine
obesity
tirzepatide

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1161/CIRCULATIONAHA.124.072889

Embargoed Document

DV-025710 TZP vs Glargine NT-proBNP_Manuscript Clean Accepted_12 Feb 25
Accepted author manuscript, 527 KB
Embargo ends: 13/11/25

Cite this

Sattar, N., Weerakkody, G. J., Mcguire, D. K., Kosiborod, M. N., Lee, M. M. Y., Welsh, P., Pearson, E. R., Wiese, R. J., Duffin, K., Wilson, J., Pavo, N., Hülsmann, M., & Pavo, I. (2025). The Association Between Tirzepatide Versus Insulin Glargine and NT-proBNP Levels in People With Type 2 Diabetes With or at Elevated Risk for Cardiovascular Disease: Post hoc Analyses of SURPASS 4. Circulation, 151(19), 1430-1432. https://doi.org/10.1161/CIRCULATIONAHA.124.072889

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title = "The Association Between Tirzepatide Versus Insulin Glargine and NT-proBNP Levels in People With Type 2 Diabetes With or at Elevated Risk for Cardiovascular Disease: Post hoc Analyses of SURPASS 4",

keywords = "cardiovascular diseases, diabetes mellitus, type 2, heart failure, insulin glargine, obesity, tirzepatide",

author = "Naveed Sattar and Weerakkody, \{Govinda J.\} and Mcguire, \{Darren K.\} and Kosiborod, \{Mikhail N.\} and Lee, \{Matthew M.Y.\} and Paul Welsh and Pearson, \{Ewan R.\} and Wiese, \{Russell J.\} and Kevin Duffin and Jonathan Wilson and Noemi Pavo and Martin H{\"u}lsmann and Imre Pavo",

year = "2025",

month = may,

day = "13",

doi = "10.1161/CIRCULATIONAHA.124.072889",

language = "English",

volume = "151",

pages = "1430--1432",

journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott Williams and Wilkins",

number = "19",

}

Sattar, N, Weerakkody, GJ, Mcguire, DK, Kosiborod, MN, Lee, MMY, Welsh, P, Pearson, ER, Wiese, RJ, Duffin, K, Wilson, J, Pavo, N, Hülsmann, M & Pavo, I 2025, 'The Association Between Tirzepatide Versus Insulin Glargine and NT-proBNP Levels in People With Type 2 Diabetes With or at Elevated Risk for Cardiovascular Disease: Post hoc Analyses of SURPASS 4', Circulation, vol. 151, no. 19, pp. 1430-1432. https://doi.org/10.1161/CIRCULATIONAHA.124.072889

The Association Between Tirzepatide Versus Insulin Glargine and NT-proBNP Levels in People With Type 2 Diabetes With or at Elevated Risk for Cardiovascular Disease: Post hoc Analyses of SURPASS 4. / Sattar, Naveed (Lead / Corresponding author); Weerakkody, Govinda J.; Mcguire, Darren K. et al.
In: Circulation, Vol. 151, No. 19, 13.05.2025, p. 1430-1432.

Research output: Contribution to journal › Letter › peer-review

TY - JOUR

T1 - The Association Between Tirzepatide Versus Insulin Glargine and NT-proBNP Levels in People With Type 2 Diabetes With or at Elevated Risk for Cardiovascular Disease

T2 - Post hoc Analyses of SURPASS 4

AU - Sattar, Naveed

AU - Weerakkody, Govinda J.

AU - Mcguire, Darren K.

AU - Kosiborod, Mikhail N.

AU - Lee, Matthew M.Y.

AU - Welsh, Paul

AU - Pearson, Ewan R.

AU - Wiese, Russell J.

AU - Duffin, Kevin

AU - Wilson, Jonathan

AU - Pavo, Noemi

AU - Hülsmann, Martin

AU - Pavo, Imre

PY - 2025/5/13

Y1 - 2025/5/13

KW - cardiovascular diseases

KW - diabetes mellitus, type 2

KW - heart failure

KW - insulin glargine

KW - obesity

KW - tirzepatide

U2 - 10.1161/CIRCULATIONAHA.124.072889

DO - 10.1161/CIRCULATIONAHA.124.072889

M3 - Letter

C2 - 40354448

AN - SCOPUS:105005360195

SN - 0009-7322

VL - 151

SP - 1430

EP - 1432

JO - Circulation

JF - Circulation

IS - 19

ER -

Sattar N, Weerakkody GJ, Mcguire DK, Kosiborod MN, Lee MMY, Welsh P et al. The Association Between Tirzepatide Versus Insulin Glargine and NT-proBNP Levels in People With Type 2 Diabetes With or at Elevated Risk for Cardiovascular Disease: Post hoc Analyses of SURPASS 4. Circulation. 2025 May 13;151(19):1430-1432. Epub 2025 May 12. doi: 10.1161/CIRCULATIONAHA.124.072889