The association of viral infection and chronic allograft nephropathy with graft dysfunction after renal transplantation

C. Y. William Tong, Ali Bakran, J. S. Malik Peiris, Peter Muir, C. Simon Herrington

    Research output: Contribution to journalArticle

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    Abstract

    Background. The long-term effect of viral infections on graft dysfunction and rejection after renal transplantation is uncertain.

    Methods. A cohort of 37 renal transplant recipients was followed prospectively for 3 years. Creatinine clearance rate at 6 months and 3 years and chronic allograft nephropathy were correlated with the detection of cytomegalovirus (CMV), human herpesvirus 6 and human herpesvirus 7 and BK virus DNA, CMV disease, and acute rejection.

    Results. CMV disease was significantly associated with poor graft function at 6 months, whereas chronic allograft nephropathy was associated with graft dysfunction at 3 years. Both CMV disease and detection of human herpesvirus 6 DNA were associated with chronic allograft nephropathy.

    Conclusions. CMV disease was a significant cause of early graft dysfunction, whereas the presence of chronic allograft nephropathy was the main determinant of poor long-term graft function. The role of viral infections in chronic allograft nephropathy deserves further investigation.
    Original languageEnglish
    Pages (from-to)576-578
    Number of pages3
    JournalTransplantation
    Volume74
    Issue number4
    Publication statusPublished - 2002

    Cite this

    Tong, C. Y. W., Bakran, A., Peiris, J. S. M., Muir, P., & Herrington, C. S. (2002). The association of viral infection and chronic allograft nephropathy with graft dysfunction after renal transplantation. Transplantation, 74(4), 576-578.
    Tong, C. Y. William ; Bakran, Ali ; Peiris, J. S. Malik ; Muir, Peter ; Herrington, C. Simon. / The association of viral infection and chronic allograft nephropathy with graft dysfunction after renal transplantation. In: Transplantation. 2002 ; Vol. 74, No. 4. pp. 576-578.
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    title = "The association of viral infection and chronic allograft nephropathy with graft dysfunction after renal transplantation",
    abstract = "Background. The long-term effect of viral infections on graft dysfunction and rejection after renal transplantation is uncertain.Methods. A cohort of 37 renal transplant recipients was followed prospectively for 3 years. Creatinine clearance rate at 6 months and 3 years and chronic allograft nephropathy were correlated with the detection of cytomegalovirus (CMV), human herpesvirus 6 and human herpesvirus 7 and BK virus DNA, CMV disease, and acute rejection.Results. CMV disease was significantly associated with poor graft function at 6 months, whereas chronic allograft nephropathy was associated with graft dysfunction at 3 years. Both CMV disease and detection of human herpesvirus 6 DNA were associated with chronic allograft nephropathy.Conclusions. CMV disease was a significant cause of early graft dysfunction, whereas the presence of chronic allograft nephropathy was the main determinant of poor long-term graft function. The role of viral infections in chronic allograft nephropathy deserves further investigation.",
    author = "Tong, {C. Y. William} and Ali Bakran and Peiris, {J. S. Malik} and Peter Muir and Herrington, {C. Simon}",
    year = "2002",
    language = "English",
    volume = "74",
    pages = "576--578",
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    Tong, CYW, Bakran, A, Peiris, JSM, Muir, P & Herrington, CS 2002, 'The association of viral infection and chronic allograft nephropathy with graft dysfunction after renal transplantation', Transplantation, vol. 74, no. 4, pp. 576-578.

    The association of viral infection and chronic allograft nephropathy with graft dysfunction after renal transplantation. / Tong, C. Y. William ; Bakran, Ali ; Peiris, J. S. Malik ; Muir, Peter ; Herrington, C. Simon.

    In: Transplantation, Vol. 74, No. 4, 2002, p. 576-578.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - The association of viral infection and chronic allograft nephropathy with graft dysfunction after renal transplantation

    AU - Tong, C. Y. William

    AU - Bakran, Ali

    AU - Peiris, J. S. Malik

    AU - Muir, Peter

    AU - Herrington, C. Simon

    PY - 2002

    Y1 - 2002

    N2 - Background. The long-term effect of viral infections on graft dysfunction and rejection after renal transplantation is uncertain.Methods. A cohort of 37 renal transplant recipients was followed prospectively for 3 years. Creatinine clearance rate at 6 months and 3 years and chronic allograft nephropathy were correlated with the detection of cytomegalovirus (CMV), human herpesvirus 6 and human herpesvirus 7 and BK virus DNA, CMV disease, and acute rejection.Results. CMV disease was significantly associated with poor graft function at 6 months, whereas chronic allograft nephropathy was associated with graft dysfunction at 3 years. Both CMV disease and detection of human herpesvirus 6 DNA were associated with chronic allograft nephropathy.Conclusions. CMV disease was a significant cause of early graft dysfunction, whereas the presence of chronic allograft nephropathy was the main determinant of poor long-term graft function. The role of viral infections in chronic allograft nephropathy deserves further investigation.

    AB - Background. The long-term effect of viral infections on graft dysfunction and rejection after renal transplantation is uncertain.Methods. A cohort of 37 renal transplant recipients was followed prospectively for 3 years. Creatinine clearance rate at 6 months and 3 years and chronic allograft nephropathy were correlated with the detection of cytomegalovirus (CMV), human herpesvirus 6 and human herpesvirus 7 and BK virus DNA, CMV disease, and acute rejection.Results. CMV disease was significantly associated with poor graft function at 6 months, whereas chronic allograft nephropathy was associated with graft dysfunction at 3 years. Both CMV disease and detection of human herpesvirus 6 DNA were associated with chronic allograft nephropathy.Conclusions. CMV disease was a significant cause of early graft dysfunction, whereas the presence of chronic allograft nephropathy was the main determinant of poor long-term graft function. The role of viral infections in chronic allograft nephropathy deserves further investigation.

    M3 - Article

    VL - 74

    SP - 576

    EP - 578

    JO - Transplantation

    JF - Transplantation

    SN - 0041-1337

    IS - 4

    ER -