The association of viral infection and chronic allograft nephropathy with graft dysfunction after renal transplantation

TY - JOUR

T1 - The association of viral infection and chronic allograft nephropathy with graft dysfunction after renal transplantation

AU - Tong, C. Y. William

AU - Bakran, Ali

AU - Peiris, J. S. Malik

AU - Muir, Peter

AU - Herrington, C. Simon

PY - 2002

Y1 - 2002

N2 - Background. The long-term effect of viral infections on graft dysfunction and rejection after renal transplantation is uncertain. Methods. A cohort of 37 renal transplant recipients was followed prospectively for 3 years. Creatinine clearance rate at 6 months and 3 years and chronic allograft nephropathy were correlated with the detection of cytomegalovirus (CMV), human herpesvirus 6 and human herpesvirus 7 and BK virus DNA, CMV disease, and acute rejection. Results. CMV disease was significantly associated with poor graft function at 6 months, whereas chronic allograft nephropathy was associated with graft dysfunction at 3 years. Both CMV disease and detection of human herpesvirus 6 DNA were associated with chronic allograft nephropathy. Conclusions. CMV disease was a significant cause of early graft dysfunction, whereas the presence of chronic allograft nephropathy was the main determinant of poor long-term graft function. The role of viral infections in chronic allograft nephropathy deserves further investigation.

AB - Background. The long-term effect of viral infections on graft dysfunction and rejection after renal transplantation is uncertain. Methods. A cohort of 37 renal transplant recipients was followed prospectively for 3 years. Creatinine clearance rate at 6 months and 3 years and chronic allograft nephropathy were correlated with the detection of cytomegalovirus (CMV), human herpesvirus 6 and human herpesvirus 7 and BK virus DNA, CMV disease, and acute rejection. Results. CMV disease was significantly associated with poor graft function at 6 months, whereas chronic allograft nephropathy was associated with graft dysfunction at 3 years. Both CMV disease and detection of human herpesvirus 6 DNA were associated with chronic allograft nephropathy. Conclusions. CMV disease was a significant cause of early graft dysfunction, whereas the presence of chronic allograft nephropathy was the main determinant of poor long-term graft function. The role of viral infections in chronic allograft nephropathy deserves further investigation.

M3 - Article

SN - 0041-1337

VL - 74

SP - 576

EP - 578

JO - Transplantation

JF - Transplantation

IS - 4

ER -