The Bacillus subtilis DivIVA protein targets to the division septum and controls the site specificity of cell division

David H. Edwards, Jeffery Errington

    Research output: Contribution to journalArticle

    220 Citations (Scopus)

    Abstract

    The Bacillus subtilis divIVA gene, first defined by a mutation giving rise to anucleate minicells, has been cloned and characterized. Depletion of DivIVA leads to inhibition of the initiation of cell division. The residual divisions that do occur are abnormally placed and sometimes misorientated relative to the long axis of the cell. The DivIVA phenotype can be suppressed by disruption of the MinCD division inhibitor, suggesting that DivIVA controls the topological specificity of MinCD action and thus septum positioning. A DivIVA-GFP fusion targets to new and used sites of cell division, consistent with it having a direct role in topological specification.
    Original languageEnglish
    Pages (from-to)905-915
    Number of pages11
    JournalMolecular Microbiology
    Volume24
    Issue number5
    DOIs
    Publication statusPublished - Jun 1997

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