TY - JOUR
T1 - The Bacillus subtilis DivIVA protein targets to the division septum and controls the site specificity of cell division
AU - Edwards, David H.
AU - Errington, Jeffery
PY - 1997/6
Y1 - 1997/6
N2 - The Bacillus subtilis divIVA gene, first defined by a mutation giving rise to anucleate minicells, has been cloned and characterized. Depletion of DivIVA leads to inhibition of the initiation of cell division. The residual divisions that do occur are abnormally placed and sometimes misorientated relative to the long axis of the cell. The DivIVA phenotype can be suppressed by disruption of the MinCD division inhibitor, suggesting that DivIVA controls the topological specificity of MinCD action and thus septum positioning. A DivIVA-GFP fusion targets to new and used sites of cell division, consistent with it having a direct role in topological specification.
AB - The Bacillus subtilis divIVA gene, first defined by a mutation giving rise to anucleate minicells, has been cloned and characterized. Depletion of DivIVA leads to inhibition of the initiation of cell division. The residual divisions that do occur are abnormally placed and sometimes misorientated relative to the long axis of the cell. The DivIVA phenotype can be suppressed by disruption of the MinCD division inhibitor, suggesting that DivIVA controls the topological specificity of MinCD action and thus septum positioning. A DivIVA-GFP fusion targets to new and used sites of cell division, consistent with it having a direct role in topological specification.
U2 - 10.1046/j.1365-2958.1997.3811764.x
DO - 10.1046/j.1365-2958.1997.3811764.x
M3 - Article
C2 - 9219999
SN - 0950-382X
VL - 24
SP - 905
EP - 915
JO - Molecular Microbiology
JF - Molecular Microbiology
IS - 5
ER -