The balancing act of neutrophils

Bart W. Bardoel; Elaine F. Kenny; Gabriel Sollberger; Arturo Zychlinsky

doi:10.1016/j.chom.2014.04.011

The balancing act of neutrophils

Bart W. Bardoel, Elaine F. Kenny, Gabriel Sollberger, Arturo Zychlinsky (Lead / Corresponding author)

Cell Signalling and Immunology

Research output: Contribution to journal › Review article › peer-review

166 Citations (Scopus)

Abstract

Neutrophils are endowed with a plethora of toxic molecules that are mobilized in immune responses. These cells evolved to fight infections, but when deployed at the wrong time and in the wrong place, they cause damage to the host. Here, we review the generalities of these cells as well as the difficulties encountered when trying to unravel them mechanistically. We then focus on how neutrophils develop and their function in infection. We center our attention on human neutrophils and what we learn from clinical immunodeficiencies. Finally, we use autoimmune disease to illustrate the harmful potential of dysregulated neutrophil responses.

Original language	English
Pages (from-to)	526-536
Number of pages	11
Journal	Cell Host and Microbe
Volume	15
Issue number	5
Early online date	14 May 2014
DOIs	https://doi.org/10.1016/j.chom.2014.04.011
Publication status	Published - 14 May 2014

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.chom.2014.04.011Licence: Elsevier User Licence

Cite this

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abstract = "Neutrophils are endowed with a plethora of toxic molecules that are mobilized in immune responses. These cells evolved to fight infections, but when deployed at the wrong time and in the wrong place, they cause damage to the host. Here, we review the generalities of these cells as well as the difficulties encountered when trying to unravel them mechanistically. We then focus on how neutrophils develop and their function in infection. We center our attention on human neutrophils and what we learn from clinical immunodeficiencies. Finally, we use autoimmune disease to illustrate the harmful potential of dysregulated neutrophil responses.",

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N2 - Neutrophils are endowed with a plethora of toxic molecules that are mobilized in immune responses. These cells evolved to fight infections, but when deployed at the wrong time and in the wrong place, they cause damage to the host. Here, we review the generalities of these cells as well as the difficulties encountered when trying to unravel them mechanistically. We then focus on how neutrophils develop and their function in infection. We center our attention on human neutrophils and what we learn from clinical immunodeficiencies. Finally, we use autoimmune disease to illustrate the harmful potential of dysregulated neutrophil responses.

AB - Neutrophils are endowed with a plethora of toxic molecules that are mobilized in immune responses. These cells evolved to fight infections, but when deployed at the wrong time and in the wrong place, they cause damage to the host. Here, we review the generalities of these cells as well as the difficulties encountered when trying to unravel them mechanistically. We then focus on how neutrophils develop and their function in infection. We center our attention on human neutrophils and what we learn from clinical immunodeficiencies. Finally, we use autoimmune disease to illustrate the harmful potential of dysregulated neutrophil responses.

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DO - 10.1016/j.chom.2014.04.011

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ER -

The balancing act of neutrophils

Abstract

ASJC Scopus subject areas

UN SDGs

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