The balancing act of neutrophils

Bart W. Bardoel, Elaine F. Kenny, Gabriel Sollberger, Arturo Zychlinsky (Lead / Corresponding author)

Research output: Contribution to journalReview article

87 Citations (Scopus)

Abstract

Neutrophils are endowed with a plethora of toxic molecules that are mobilized in immune responses. These cells evolved to fight infections, but when deployed at the wrong time and in the wrong place, they cause damage to the host. Here, we review the generalities of these cells as well as the difficulties encountered when trying to unravel them mechanistically. We then focus on how neutrophils develop and their function in infection. We center our attention on human neutrophils and what we learn from clinical immunodeficiencies. Finally, we use autoimmune disease to illustrate the harmful potential of dysregulated neutrophil responses.

Original languageEnglish
Pages (from-to)526-536
Number of pages11
JournalCell Host and Microbe
Volume15
Issue number5
Early online date14 May 2014
DOIs
Publication statusPublished - 14 May 2014

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    Bardoel, B. W., Kenny, E. F., Sollberger, G., & Zychlinsky, A. (2014). The balancing act of neutrophils. Cell Host and Microbe, 15(5), 526-536. https://doi.org/10.1016/j.chom.2014.04.011