The balancing act of neutrophils

TY - JOUR

T1 - The balancing act of neutrophils

AU - Bardoel, Bart W.

AU - Kenny, Elaine F.

AU - Sollberger, Gabriel

AU - Zychlinsky, Arturo

PY - 2014/5/14

Y1 - 2014/5/14

N2 - Neutrophils are endowed with a plethora of toxic molecules that are mobilized in immune responses. These cells evolved to fight infections, but when deployed at the wrong time and in the wrong place, they cause damage to the host. Here, we review the generalities of these cells as well as the difficulties encountered when trying to unravel them mechanistically. We then focus on how neutrophils develop and their function in infection. We center our attention on human neutrophils and what we learn from clinical immunodeficiencies. Finally, we use autoimmune disease to illustrate the harmful potential of dysregulated neutrophil responses.

AB - Neutrophils are endowed with a plethora of toxic molecules that are mobilized in immune responses. These cells evolved to fight infections, but when deployed at the wrong time and in the wrong place, they cause damage to the host. Here, we review the generalities of these cells as well as the difficulties encountered when trying to unravel them mechanistically. We then focus on how neutrophils develop and their function in infection. We center our attention on human neutrophils and what we learn from clinical immunodeficiencies. Finally, we use autoimmune disease to illustrate the harmful potential of dysregulated neutrophil responses.

UR - https://www.scopus.com/pages/publications/84901020612

U2 - 10.1016/j.chom.2014.04.011

DO - 10.1016/j.chom.2014.04.011

M3 - Review article

C2 - 24832448

AN - SCOPUS:84901020612

SN - 1931-3128

VL - 15

SP - 526

EP - 536

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 5

ER -