The barley immune receptor Mla recognizes multiple pathogens and contributes to host range dynamics

Jan Bettgenhaeuser; Inmaculada Hernández-Pinzón; Andrew M. Dawson; Matthew Gardiner; Phon Green; Jodie Taylor; Matthew Smoker; John N. Ferguson; Peter Emmrich; Amelia Hubbard; Rosemary Bayles; Robbie Waugh; Brian J. Steffenson; Brande B. H. Wulff; Antonín Dreiseitl; Eric R. Ward; Matthew J. Moscou

doi:10.1038/s41467-021-27288-3

The barley immune receptor Mla recognizes multiple pathogens and contributes to host range dynamics

Jan Bettgenhaeuser, Inmaculada Hernández-Pinzón, Andrew M. Dawson, Matthew Gardiner, Phon Green, Jodie Taylor, Matthew Smoker, John N. Ferguson, Peter Emmrich, Amelia Hubbard, Rosemary Bayles, Robbie Waugh, Brian J. Steffenson, Brande B. H. Wulff, Antonín Dreiseitl, Eric R. Ward, Matthew J. Moscou (Lead / Corresponding author)

Plant Sciences

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27 Citations (Scopus)

102 Downloads (Pure)

Abstract

Crop losses caused by plant pathogens are a primary threat to stable food production. Stripe rust (Puccinia striiformis) is a fungal pathogen of cereal crops that causes significant, persistent yield loss. Stripe rust exhibits host species specificity, with lineages that have adapted to infect wheat and barley. While wheat stripe rust and barley stripe rust are commonly restricted to their corresponding hosts, the genes underlying this host specificity remain unknown. Here, we show that three resistance genes, Rps6, Rps7, and Rps8, contribute to immunity in barley to wheat stripe rust. Rps7 cosegregates with barley powdery mildew resistance at the Mla locus. Using transgenic complementation of different Mla alleles, we confirm allele-specific recognition of wheat stripe rust by Mla. Our results show that major resistance genes contribute to the host species specificity of wheat stripe rust on barley and that a shared genetic architecture underlies resistance to the adapted pathogen barley powdery mildew and non-adapted pathogen wheat stripe rust.

Original language	English
Article number	6915
Number of pages	14
Journal	Nature Communications
Volume	12
DOIs	https://doi.org/10.1038/s41467-021-27288-3
Publication status	Published - 25 Nov 2021

Keywords

Agricultural genetics
Biotic
Plant breeding
Plant immunity

ASJC Scopus subject areas

General Physics and Astronomy
General Chemistry
General Biochemistry,Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41467-021-27288-3Licence: CC BY

Final Published VersionFinal published version, 3.45 MBLicence: CC BY

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Bettgenhaeuser, J., Hernández-Pinzón, I., Dawson, A. M., Gardiner, M., Green, P., Taylor, J., Smoker, M., Ferguson, J. N., Emmrich, P., Hubbard, A., Bayles, R., Waugh, R., Steffenson, B. J., Wulff, B. B. H., Dreiseitl, A., Ward, E. R., & Moscou, M. J. (2021). The barley immune receptor Mla recognizes multiple pathogens and contributes to host range dynamics. Nature Communications, 12, Article 6915. https://doi.org/10.1038/s41467-021-27288-3

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title = "The barley immune receptor Mla recognizes multiple pathogens and contributes to host range dynamics",

abstract = "Crop losses caused by plant pathogens are a primary threat to stable food production. Stripe rust (Puccinia striiformis) is a fungal pathogen of cereal crops that causes significant, persistent yield loss. Stripe rust exhibits host species specificity, with lineages that have adapted to infect wheat and barley. While wheat stripe rust and barley stripe rust are commonly restricted to their corresponding hosts, the genes underlying this host specificity remain unknown. Here, we show that three resistance genes, Rps6, Rps7, and Rps8, contribute to immunity in barley to wheat stripe rust. Rps7 cosegregates with barley powdery mildew resistance at the Mla locus. Using transgenic complementation of different Mla alleles, we confirm allele-specific recognition of wheat stripe rust by Mla. Our results show that major resistance genes contribute to the host species specificity of wheat stripe rust on barley and that a shared genetic architecture underlies resistance to the adapted pathogen barley powdery mildew and non-adapted pathogen wheat stripe rust.",

keywords = "Agricultural genetics, Biotic, Plant breeding, Plant immunity",

author = "Jan Bettgenhaeuser and Inmaculada Hern{\'a}ndez-Pinz{\'o}n and Dawson, {Andrew M.} and Matthew Gardiner and Phon Green and Jodie Taylor and Matthew Smoker and Ferguson, {John N.} and Peter Emmrich and Amelia Hubbard and Rosemary Bayles and Robbie Waugh and Steffenson, {Brian J.} and Wulff, {Brande B. H.} and Anton{\'i}n Dreiseitl and Ward, {Eric R.} and Moscou, {Matthew J.}",

note = "Funding for this research includes Biotechnology and Biological Sciences Research Council Doctoral Training Programme (grant no. BB/F017294/1 to J.B. and M.J.M.) and Institute Strategic Programme (grant no. BB/J004553/1 to B.B.H.W., BB/P012574/1 to M.J.M., and BBS/E/J/000PR9795 to M.J.M.), Human Frontier Science Program Long-term Fellowship (grant no. LT000218/2011-L to M.J.M.), John Innes Foundation (rotation PhD studentship to PE), 2Blades Foundation, and Gatsby Charitable Foundation. {\textcopyright} 2021. The Author(s).",

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month = nov,

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doi = "10.1038/s41467-021-27288-3",

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Bettgenhaeuser, J, Hernández-Pinzón, I, Dawson, AM, Gardiner, M, Green, P, Taylor, J, Smoker, M, Ferguson, JN, Emmrich, P, Hubbard, A, Bayles, R, Waugh, R, Steffenson, BJ, Wulff, BBH, Dreiseitl, A, Ward, ER & Moscou, MJ 2021, 'The barley immune receptor Mla recognizes multiple pathogens and contributes to host range dynamics', Nature Communications, vol. 12, 6915. https://doi.org/10.1038/s41467-021-27288-3

TY - JOUR

T1 - The barley immune receptor Mla recognizes multiple pathogens and contributes to host range dynamics

AU - Bettgenhaeuser, Jan

AU - Hernández-Pinzón, Inmaculada

AU - Dawson, Andrew M.

AU - Gardiner, Matthew

AU - Green, Phon

AU - Taylor, Jodie

AU - Smoker, Matthew

AU - Ferguson, John N.

AU - Emmrich, Peter

AU - Hubbard, Amelia

AU - Bayles, Rosemary

AU - Waugh, Robbie

AU - Steffenson, Brian J.

AU - Wulff, Brande B. H.

AU - Dreiseitl, Antonín

AU - Ward, Eric R.

AU - Moscou, Matthew J.

N1 - Funding for this research includes Biotechnology and Biological Sciences Research Council Doctoral Training Programme (grant no. BB/F017294/1 to J.B. and M.J.M.) and Institute Strategic Programme (grant no. BB/J004553/1 to B.B.H.W., BB/P012574/1 to M.J.M., and BBS/E/J/000PR9795 to M.J.M.), Human Frontier Science Program Long-term Fellowship (grant no. LT000218/2011-L to M.J.M.), John Innes Foundation (rotation PhD studentship to PE), 2Blades Foundation, and Gatsby Charitable Foundation. © 2021. The Author(s).

PY - 2021/11/25

Y1 - 2021/11/25

N2 - Crop losses caused by plant pathogens are a primary threat to stable food production. Stripe rust (Puccinia striiformis) is a fungal pathogen of cereal crops that causes significant, persistent yield loss. Stripe rust exhibits host species specificity, with lineages that have adapted to infect wheat and barley. While wheat stripe rust and barley stripe rust are commonly restricted to their corresponding hosts, the genes underlying this host specificity remain unknown. Here, we show that three resistance genes, Rps6, Rps7, and Rps8, contribute to immunity in barley to wheat stripe rust. Rps7 cosegregates with barley powdery mildew resistance at the Mla locus. Using transgenic complementation of different Mla alleles, we confirm allele-specific recognition of wheat stripe rust by Mla. Our results show that major resistance genes contribute to the host species specificity of wheat stripe rust on barley and that a shared genetic architecture underlies resistance to the adapted pathogen barley powdery mildew and non-adapted pathogen wheat stripe rust.

AB - Crop losses caused by plant pathogens are a primary threat to stable food production. Stripe rust (Puccinia striiformis) is a fungal pathogen of cereal crops that causes significant, persistent yield loss. Stripe rust exhibits host species specificity, with lineages that have adapted to infect wheat and barley. While wheat stripe rust and barley stripe rust are commonly restricted to their corresponding hosts, the genes underlying this host specificity remain unknown. Here, we show that three resistance genes, Rps6, Rps7, and Rps8, contribute to immunity in barley to wheat stripe rust. Rps7 cosegregates with barley powdery mildew resistance at the Mla locus. Using transgenic complementation of different Mla alleles, we confirm allele-specific recognition of wheat stripe rust by Mla. Our results show that major resistance genes contribute to the host species specificity of wheat stripe rust on barley and that a shared genetic architecture underlies resistance to the adapted pathogen barley powdery mildew and non-adapted pathogen wheat stripe rust.

KW - Agricultural genetics

KW - Biotic

KW - Plant breeding

KW - Plant immunity

UR - http://www.scopus.com/inward/record.url?scp=85119838248&partnerID=8YFLogxK

U2 - 10.1038/s41467-021-27288-3

DO - 10.1038/s41467-021-27288-3

M3 - Article

C2 - 34824299

SN - 2041-1723

VL - 12

JO - Nature Communications

JF - Nature Communications

M1 - 6915

ER -

The barley immune receptor Mla recognizes multiple pathogens and contributes to host range dynamics

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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