The BRICS (Bronchiectasis Radiologically Indexed CT Score)- a multi-center study score for use in idiopathic and post infective bronchiectasis

Pallavi Bedi; J. D. Chalmers; Pieter C. Goeminne; Cindy Mai; Pira Saravanamuthu; Prasad Palani Velu; Manjit K. Cartlidge; Michael R. Loebinger; Joe Jacob; Faisal Kamal; Nicola Schembri; Stefano Aliberti; Uta Hill; Mike Harrison; Christopher Johnson; Nicholas Screaton; Charles Haworth; Eva Polverino; Edmundo Rosales; Antoni Torres; Michael N. Benegas; Adriano G. Rossi; Dilip Patel; Adam T. Hill

doi:10.1016/j.chest.2017.11.033

The BRICS (Bronchiectasis Radiologically Indexed CT Score)- a multi-center study score for use in idiopathic and post infective bronchiectasis

Pallavi Bedi (Lead / Corresponding author), J. D. Chalmers, Pieter C. Goeminne, Cindy Mai, Pira Saravanamuthu, Prasad Palani Velu, Manjit K. Cartlidge, Michael R. Loebinger, Joe Jacob, Faisal Kamal, Nicola Schembri, Stefano Aliberti, Uta Hill, Mike Harrison, Christopher Johnson, Nicholas Screaton, Charles Haworth, Eva Polverino, Edmundo Rosales, Antoni TorresMichael N. Benegas, Adriano G. Rossi, Dilip Patel, Adam T. Hill

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Abstract

Objectives: The aim of our study was to develop a simplified radiological score that could assess clinical disease severity in bronchiectasis.

Methods: The BRICS (Bronchiectasis Radiologically Indexed CT Score) was devised based on multivariable analysis of the Bhalla score and their ability in predicting clinical parameters of severity. The score was then externally validated in 6 centers in 302 patients.

Result: 184 HRCT scans were scored for the validation cohort. In a multiple logistic regression model, disease severity markers significantly associated with the Bhalla score were percentage predicted FEV1, sputum purulence and exacerbations requiring hospital admission. Components of the Bhalla score that were significantly associated with the disease severity markers were bronchial dilatation and number of bronchopulmonary segments with emphysema. The BRICS was developed with these two parameters. The receiver operator curve values for BRICS in the derivation cohort were 0.79 for percentage predicted FEV1, 0.71 for sputum purulence and 0.75 for hospital admissions/year; and 0.81, 0.70 and 0.70 respectively in the validation cohort. Sputum free neutrophil elastase was significantly elevated in the group with emphysema on CT.

Conclusion: A simplified CT scoring system can be used as an adjunct to clinical parameters to predict disease severity in patients with idiopathic and post-infective bronchiectasis.

Original language	English
Pages (from-to)	1177-1186
Number of pages	10
Journal	Chest
Volume	153
Issue number	5
Early online date	13 Dec 2017
DOIs	https://doi.org/10.1016/j.chest.2017.11.033
Publication status	Published - May 2018

Keywords

Journal article
bronchiectasis
CT scan
scoring system

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10.1016/j.chest.2017.11.033

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Bedi, P., Chalmers, J. D., Goeminne, P. C., Mai, C., Saravanamuthu, P., Velu, P. P., Cartlidge, M. K., Loebinger, M. R., Jacob, J., Kamal, F., Schembri, N., Aliberti, S., Hill, U., Harrison, M., Johnson, C., Screaton, N., Haworth, C., Polverino, E., Rosales, E., ... Hill, A. T. (2018). The BRICS (Bronchiectasis Radiologically Indexed CT Score)- a multi-center study score for use in idiopathic and post infective bronchiectasis. Chest, 153(5), 1177-1186. https://doi.org/10.1016/j.chest.2017.11.033

@article{4a480d00c11f495dbe4af18e3441a394,

title = "The BRICS (Bronchiectasis Radiologically Indexed CT Score)- a multi-center study score for use in idiopathic and post infective bronchiectasis",

abstract = "Objectives: The aim of our study was to develop a simplified radiological score that could assess clinical disease severity in bronchiectasis.Methods: The BRICS (Bronchiectasis Radiologically Indexed CT Score) was devised based on multivariable analysis of the Bhalla score and their ability in predicting clinical parameters of severity. The score was then externally validated in 6 centers in 302 patients.Result: 184 HRCT scans were scored for the validation cohort. In a multiple logistic regression model, disease severity markers significantly associated with the Bhalla score were percentage predicted FEV1, sputum purulence and exacerbations requiring hospital admission. Components of the Bhalla score that were significantly associated with the disease severity markers were bronchial dilatation and number of bronchopulmonary segments with emphysema. The BRICS was developed with these two parameters. The receiver operator curve values for BRICS in the derivation cohort were 0.79 for percentage predicted FEV1, 0.71 for sputum purulence and 0.75 for hospital admissions/year; and 0.81, 0.70 and 0.70 respectively in the validation cohort. Sputum free neutrophil elastase was significantly elevated in the group with emphysema on CT.Conclusion: A simplified CT scoring system can be used as an adjunct to clinical parameters to predict disease severity in patients with idiopathic and post-infective bronchiectasis.",

keywords = "Journal article, bronchiectasis, CT scan, scoring system",

author = "Pallavi Bedi and Chalmers, {J. D.} and Goeminne, {Pieter C.} and Cindy Mai and Pira Saravanamuthu and Velu, {Prasad Palani} and Cartlidge, {Manjit K.} and Loebinger, {Michael R.} and Joe Jacob and Faisal Kamal and Nicola Schembri and Stefano Aliberti and Uta Hill and Mike Harrison and Christopher Johnson and Nicholas Screaton and Charles Haworth and Eva Polverino and Edmundo Rosales and Antoni Torres and Benegas, {Michael N.} and Rossi, {Adriano G.} and Dilip Patel and Hill, {Adam T.}",

note = "JJ has received consultant fees from Boehringer Ingelheim. MH has received speaking fees from Vertex Pharmaceuticals.",

year = "2018",

month = may,

doi = "10.1016/j.chest.2017.11.033",

language = "English",

volume = "153",

pages = "1177--1186",

journal = "Chest",

issn = "0012-3692",

publisher = "Elsevier",

number = "5",

}

Bedi, P, Chalmers, JD, Goeminne, PC, Mai, C, Saravanamuthu, P, Velu, PP, Cartlidge, MK, Loebinger, MR, Jacob, J, Kamal, F, Schembri, N, Aliberti, S, Hill, U, Harrison, M, Johnson, C, Screaton, N, Haworth, C, Polverino, E, Rosales, E, Torres, A, Benegas, MN, Rossi, AG, Patel, D & Hill, AT 2018, 'The BRICS (Bronchiectasis Radiologically Indexed CT Score)- a multi-center study score for use in idiopathic and post infective bronchiectasis', Chest, vol. 153, no. 5, pp. 1177-1186. https://doi.org/10.1016/j.chest.2017.11.033

TY - JOUR

T1 - The BRICS (Bronchiectasis Radiologically Indexed CT Score)- a multi-center study score for use in idiopathic and post infective bronchiectasis

AU - Bedi, Pallavi

AU - Chalmers, J. D.

AU - Goeminne, Pieter C.

AU - Mai, Cindy

AU - Saravanamuthu, Pira

AU - Velu, Prasad Palani

AU - Cartlidge, Manjit K.

AU - Loebinger, Michael R.

AU - Jacob, Joe

AU - Kamal, Faisal

AU - Schembri, Nicola

AU - Aliberti, Stefano

AU - Hill, Uta

AU - Harrison, Mike

AU - Johnson, Christopher

AU - Screaton, Nicholas

AU - Haworth, Charles

AU - Polverino, Eva

AU - Rosales, Edmundo

AU - Torres, Antoni

AU - Benegas, Michael N.

AU - Rossi, Adriano G.

AU - Patel, Dilip

AU - Hill, Adam T.

N1 - JJ has received consultant fees from Boehringer Ingelheim. MH has received speaking fees from Vertex Pharmaceuticals.

PY - 2018/5

Y1 - 2018/5

N2 - Objectives: The aim of our study was to develop a simplified radiological score that could assess clinical disease severity in bronchiectasis.Methods: The BRICS (Bronchiectasis Radiologically Indexed CT Score) was devised based on multivariable analysis of the Bhalla score and their ability in predicting clinical parameters of severity. The score was then externally validated in 6 centers in 302 patients.Result: 184 HRCT scans were scored for the validation cohort. In a multiple logistic regression model, disease severity markers significantly associated with the Bhalla score were percentage predicted FEV1, sputum purulence and exacerbations requiring hospital admission. Components of the Bhalla score that were significantly associated with the disease severity markers were bronchial dilatation and number of bronchopulmonary segments with emphysema. The BRICS was developed with these two parameters. The receiver operator curve values for BRICS in the derivation cohort were 0.79 for percentage predicted FEV1, 0.71 for sputum purulence and 0.75 for hospital admissions/year; and 0.81, 0.70 and 0.70 respectively in the validation cohort. Sputum free neutrophil elastase was significantly elevated in the group with emphysema on CT.Conclusion: A simplified CT scoring system can be used as an adjunct to clinical parameters to predict disease severity in patients with idiopathic and post-infective bronchiectasis.

AB - Objectives: The aim of our study was to develop a simplified radiological score that could assess clinical disease severity in bronchiectasis.Methods: The BRICS (Bronchiectasis Radiologically Indexed CT Score) was devised based on multivariable analysis of the Bhalla score and their ability in predicting clinical parameters of severity. The score was then externally validated in 6 centers in 302 patients.Result: 184 HRCT scans were scored for the validation cohort. In a multiple logistic regression model, disease severity markers significantly associated with the Bhalla score were percentage predicted FEV1, sputum purulence and exacerbations requiring hospital admission. Components of the Bhalla score that were significantly associated with the disease severity markers were bronchial dilatation and number of bronchopulmonary segments with emphysema. The BRICS was developed with these two parameters. The receiver operator curve values for BRICS in the derivation cohort were 0.79 for percentage predicted FEV1, 0.71 for sputum purulence and 0.75 for hospital admissions/year; and 0.81, 0.70 and 0.70 respectively in the validation cohort. Sputum free neutrophil elastase was significantly elevated in the group with emphysema on CT.Conclusion: A simplified CT scoring system can be used as an adjunct to clinical parameters to predict disease severity in patients with idiopathic and post-infective bronchiectasis.

KW - Journal article

KW - bronchiectasis

KW - CT scan

KW - scoring system

U2 - 10.1016/j.chest.2017.11.033

DO - 10.1016/j.chest.2017.11.033

M3 - Article

C2 - 29247616

SN - 0012-3692

VL - 153

SP - 1177

EP - 1186

JO - Chest

JF - Chest

IS - 5

ER -

The BRICS (Bronchiectasis Radiologically Indexed CT Score)- a multi-center study score for use in idiopathic and post infective bronchiectasis

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