Abstract
Aims: Ovarian gynandroblastomas are rare tumours that, by definition, comprise a combinationof components resembling both female, typically granulosa cell tumour (GCT), and male, typically Sertoli or Sertoli/Leydig cell tumour (ST/SLT), sex cord/stromal differentiation. The histogenesis of these tumours is unknown and, in view of the very strong association between the C134W (402 C> G) FOXL2 mutation and adult- type GCT, we analysed a series of gynandroblastomas for this mutation.
Methods and results: Both components of each lesion were isolated by laser capture microdissection and the C134W (402 C> G) FOXL2 mutation was analysed by polymerase chain reaction sequencing. No mutation was identified in either the GCT or ST / SLT component of six cases, three of which contained adult- type GCT.
Conclusions: This suggests that, despite their similar morphological appearances, the GCT- like component of gynandroblastoma has a different molecular basis from conventional adult- type GCT. This finding underscores a more general principle that morphological similarity does not necessarily indicate molecular identity.
| Original language | English |
|---|---|
| Pages (from-to) | 838-842 |
| Number of pages | 5 |
| Journal | Histopathology |
| Volume | 60 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Apr 2012 |
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The C134W (402 C > G) FOXL2 mutation is absent in ovarian gynandroblastoma : insights into the genesis of an unusual tumour. / Oparka, Richard; Cassidy, Andrew; Reilly, Stephanie; Stenhouse, Alasdair; McCluggage, W. Glenn; Herrington, C. Simon.
In: Histopathology, Vol. 60, No. 5, 04.2012, p. 838-842.Research output: Contribution to journal › Article
TY - JOUR
T1 - The C134W (402 C > G) FOXL2 mutation is absent in ovarian gynandroblastoma
T2 - insights into the genesis of an unusual tumour
AU - Oparka, Richard
AU - Cassidy, Andrew
AU - Reilly, Stephanie
AU - Stenhouse, Alasdair
AU - McCluggage, W. Glenn
AU - Herrington, C. Simon
N1 - Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/4
Y1 - 2012/4
N2 - Aims: Ovarian gynandroblastomas are rare tumours that, by definition, comprise a combinationof components resembling both female, typically granulosa cell tumour (GCT), and male, typically Sertoli or Sertoli/Leydig cell tumour (ST/SLT), sex cord/stromal differentiation. The histogenesis of these tumours is unknown and, in view of the very strong association between the C134W (402 C> G) FOXL2 mutation and adult- type GCT, we analysed a series of gynandroblastomas for this mutation.Methods and results: Both components of each lesion were isolated by laser capture microdissection and the C134W (402 C> G) FOXL2 mutation was analysed by polymerase chain reaction sequencing. No mutation was identified in either the GCT or ST / SLT component of six cases, three of which contained adult- type GCT.Conclusions: This suggests that, despite their similar morphological appearances, the GCT- like component of gynandroblastoma has a different molecular basis from conventional adult- type GCT. This finding underscores a more general principle that morphological similarity does not necessarily indicate molecular identity.
AB - Aims: Ovarian gynandroblastomas are rare tumours that, by definition, comprise a combinationof components resembling both female, typically granulosa cell tumour (GCT), and male, typically Sertoli or Sertoli/Leydig cell tumour (ST/SLT), sex cord/stromal differentiation. The histogenesis of these tumours is unknown and, in view of the very strong association between the C134W (402 C> G) FOXL2 mutation and adult- type GCT, we analysed a series of gynandroblastomas for this mutation.Methods and results: Both components of each lesion were isolated by laser capture microdissection and the C134W (402 C> G) FOXL2 mutation was analysed by polymerase chain reaction sequencing. No mutation was identified in either the GCT or ST / SLT component of six cases, three of which contained adult- type GCT.Conclusions: This suggests that, despite their similar morphological appearances, the GCT- like component of gynandroblastoma has a different molecular basis from conventional adult- type GCT. This finding underscores a more general principle that morphological similarity does not necessarily indicate molecular identity.
UR - http://www.scopus.com/inward/record.url?scp=84858999473&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2559.2011.04148.x
DO - 10.1111/j.1365-2559.2011.04148.x
M3 - Article
VL - 60
SP - 838
EP - 842
JO - Histopathology
JF - Histopathology
SN - 0309-0167
IS - 5
ER -