The C134W (402 C > G) FOXL2 mutation is absent in ovarian gynandroblastoma

insights into the genesis of an unusual tumour

Richard Oparka, Andrew Cassidy, Stephanie Reilly, Alasdair Stenhouse, W. Glenn McCluggage, C. Simon Herrington

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    Aims: Ovarian gynandroblastomas are rare tumours that, by definition, comprise a combinationof components resembling both female, typically granulosa cell tumour (GCT), and male, typically Sertoli or Sertoli/Leydig cell tumour (ST/SLT), sex cord/stromal differentiation. The histogenesis of these tumours is unknown and, in view of the very strong association between the C134W (402 C> G) FOXL2 mutation and adult- type GCT, we analysed a series of gynandroblastomas for this mutation.

    Methods and results: Both components of each lesion were isolated by laser capture microdissection and the C134W (402 C> G) FOXL2 mutation was analysed by polymerase chain reaction sequencing. No mutation was identified in either the GCT or ST / SLT component of six cases, three of which contained adult- type GCT.

    Conclusions: This suggests that, despite their similar morphological appearances, the GCT- like component of gynandroblastoma has a different molecular basis from conventional adult- type GCT. This finding underscores a more general principle that morphological similarity does not necessarily indicate molecular identity.

    Original languageEnglish
    Pages (from-to)838-842
    Number of pages5
    JournalHistopathology
    Volume60
    Issue number5
    DOIs
    Publication statusPublished - Apr 2012

    Fingerprint

    Granulosa Cell Tumor
    Mutation
    Sex Cord-Gonadal Stromal Tumors
    Neoplasms
    Sertoli-Leydig Cell Tumor
    Laser Capture Microdissection
    Ovarian gynandroblastoma
    Polymerase Chain Reaction

    Cite this

    Oparka, Richard ; Cassidy, Andrew ; Reilly, Stephanie ; Stenhouse, Alasdair ; McCluggage, W. Glenn ; Herrington, C. Simon. / The C134W (402 C > G) FOXL2 mutation is absent in ovarian gynandroblastoma : insights into the genesis of an unusual tumour. In: Histopathology. 2012 ; Vol. 60, No. 5. pp. 838-842.
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    abstract = "Aims: Ovarian gynandroblastomas are rare tumours that, by definition, comprise a combinationof components resembling both female, typically granulosa cell tumour (GCT), and male, typically Sertoli or Sertoli/Leydig cell tumour (ST/SLT), sex cord/stromal differentiation. The histogenesis of these tumours is unknown and, in view of the very strong association between the C134W (402 C> G) FOXL2 mutation and adult- type GCT, we analysed a series of gynandroblastomas for this mutation.Methods and results: Both components of each lesion were isolated by laser capture microdissection and the C134W (402 C> G) FOXL2 mutation was analysed by polymerase chain reaction sequencing. No mutation was identified in either the GCT or ST / SLT component of six cases, three of which contained adult- type GCT.Conclusions: This suggests that, despite their similar morphological appearances, the GCT- like component of gynandroblastoma has a different molecular basis from conventional adult- type GCT. This finding underscores a more general principle that morphological similarity does not necessarily indicate molecular identity.",
    author = "Richard Oparka and Andrew Cassidy and Stephanie Reilly and Alasdair Stenhouse and McCluggage, {W. Glenn} and Herrington, {C. Simon}",
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    The C134W (402 C > G) FOXL2 mutation is absent in ovarian gynandroblastoma : insights into the genesis of an unusual tumour. / Oparka, Richard; Cassidy, Andrew; Reilly, Stephanie; Stenhouse, Alasdair; McCluggage, W. Glenn; Herrington, C. Simon.

    In: Histopathology, Vol. 60, No. 5, 04.2012, p. 838-842.

    Research output: Contribution to journalArticle

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    T1 - The C134W (402 C > G) FOXL2 mutation is absent in ovarian gynandroblastoma

    T2 - insights into the genesis of an unusual tumour

    AU - Oparka, Richard

    AU - Cassidy, Andrew

    AU - Reilly, Stephanie

    AU - Stenhouse, Alasdair

    AU - McCluggage, W. Glenn

    AU - Herrington, C. Simon

    N1 - Copyright 2012 Elsevier B.V., All rights reserved.

    PY - 2012/4

    Y1 - 2012/4

    N2 - Aims: Ovarian gynandroblastomas are rare tumours that, by definition, comprise a combinationof components resembling both female, typically granulosa cell tumour (GCT), and male, typically Sertoli or Sertoli/Leydig cell tumour (ST/SLT), sex cord/stromal differentiation. The histogenesis of these tumours is unknown and, in view of the very strong association between the C134W (402 C> G) FOXL2 mutation and adult- type GCT, we analysed a series of gynandroblastomas for this mutation.Methods and results: Both components of each lesion were isolated by laser capture microdissection and the C134W (402 C> G) FOXL2 mutation was analysed by polymerase chain reaction sequencing. No mutation was identified in either the GCT or ST / SLT component of six cases, three of which contained adult- type GCT.Conclusions: This suggests that, despite their similar morphological appearances, the GCT- like component of gynandroblastoma has a different molecular basis from conventional adult- type GCT. This finding underscores a more general principle that morphological similarity does not necessarily indicate molecular identity.

    AB - Aims: Ovarian gynandroblastomas are rare tumours that, by definition, comprise a combinationof components resembling both female, typically granulosa cell tumour (GCT), and male, typically Sertoli or Sertoli/Leydig cell tumour (ST/SLT), sex cord/stromal differentiation. The histogenesis of these tumours is unknown and, in view of the very strong association between the C134W (402 C> G) FOXL2 mutation and adult- type GCT, we analysed a series of gynandroblastomas for this mutation.Methods and results: Both components of each lesion were isolated by laser capture microdissection and the C134W (402 C> G) FOXL2 mutation was analysed by polymerase chain reaction sequencing. No mutation was identified in either the GCT or ST / SLT component of six cases, three of which contained adult- type GCT.Conclusions: This suggests that, despite their similar morphological appearances, the GCT- like component of gynandroblastoma has a different molecular basis from conventional adult- type GCT. This finding underscores a more general principle that morphological similarity does not necessarily indicate molecular identity.

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