The Cardiac Form of the Tissue-Specific SmN Protein is Identical to the Brain and Embryonic Forms of the Protein

Dianne Gerrelli, Keith Grimaldi, David Horn, Ulla Mahadeva, Neil Sharpe, David S. Latchman

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The SmN protein is a component of small nuclear ribonucleoprotein particles and closely related to the ubiquitously expressed SmB and B' splicing proteins. However, SmN is only expressed in a limited range of tissues and cell types such as brain, heart and early embryonic cells. The isolation of cDNA clones derived from the mRNA encoding SmN in different cell types has indicated that the brain and embryonic forms of the protein are identical and are encoded by a distinct gene to that encoding SmB and B'. It has been suggested however, that the cardiac form of SmN is encoded by a distinct mRNA which is derived from a different gene from that encoding the brain and embryonic forms of SmN. By using the polymerase chain reaction as well as cDNA cloning we have shown that this is not the case and that the cardiac, brain and embryonic forms of the protein are identical and are translated from the same mRNA encoded by a single gene. The significance of this finding is discussed in terms of the complex expression pattern of this gene and the possible functional role of SmN.

Original languageEnglish
Pages (from-to)321-329
Number of pages9
JournalJournal of Molecular and Cellular Cardiology
Volume25
Issue number3
DOIs
Publication statusPublished - 1 Mar 1993

Keywords

  • Gene regulation
  • RNA splicing
  • SmN

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