The CD11b-integrin (ITGAM) and systemic lupus erythematosus

S. C. Fagerholm, M. Macpherson, M. J. James, C. Sevier-Guy, C. S. Lau

    Research output: Contribution to journalArticlepeer-review

    32 Citations (Scopus)

    Abstract

    Variations at the ITGAM gene, which encodes for the CD11b chain of the Mac-1 (alphaMbeta2; CD11b/CD18; complement receptor-3) integrin, is one of the strongest genetic risk factors for systemic lupus erythematosus (SLE). More specifically, a genetic variant (rs1143679) which results in an arginine to histidine substitution at position 77 in the extracellular portion of the integrin is associated with disease. It has recently been shown that this amino acid substitution results in a dysfunctional integrin, which is deficient in mediating cell adhesion to integrin ligands, phagocytosis and in addition cannot restrict inflammatory cytokine production in macrophages. In this review, we discuss immunological functions of the Mac-1 integrin and how defects in the genetic variant of Mac-1 may relate to SLE development.
    Original languageEnglish
    Pages (from-to)657-663
    Number of pages7
    JournalLupus
    Volume22
    Issue number7
    DOIs
    Publication statusPublished - 2013

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