The cdc25 Phosphatase: Biochemistry and Regulation in the Eukaryotic Cell Cycle

Ingrid Hoffmann, Paul R. Clarke, Giulio Draetta

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Cdc25, a universally conserved M-phase inducer, is a protein phosphatase that directly dephosphorylates and activates the cdc2/cyclin B protein kinase. Recently it has been found that phosphorylation regulates the activity of cdc25 during the cell cycle. The activation of cdc25 can be mediated by cdc2/cyclin B itself thus creating a positive feedback loop. A type-2A phosphatase can specifically dephosphorylate and activate cdc25. In this article we shall review our current knowledge about the regulation of entry into mitosis by the cdc25 phosphatase and its involvement in the self-amplification of MPF in vivo

    Original languageEnglish
    Pages (from-to)151-164
    Number of pages14
    JournalAdvances in Molecular and Cell Biology
    Volume13
    Issue numberC
    DOIs
    Publication statusPublished - 1 Jan 1995

    ASJC Scopus subject areas

    • Molecular Biology
    • Cell Biology

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