The Cdc7/Dbf4 protein kinase: target of the S phase checkpoint?

Pedro Jares, Anne Donaldson, J. Julian Blow

    Research output: Contribution to journalArticle

    68 Citations (Scopus)

    Abstract

    Cdc7/Dbf4 is a protein kinase that is required for the initiation of DNA replication in eukaryotes. Recent work has provided new clues to the role that Cdc7/Dbf4 plays in this process. A range of other observations suggest that Cdc7/Dbf4 also plays another, less well characterized, role in checkpoint function and in the maintenance of genomic integrity. In this review we attempt to bring together new information to explain how Cdc7/Dbf4 may perform these two distinct functions.
    Original languageEnglish
    Pages (from-to)319-322
    Number of pages4
    JournalEMBO Reports
    Volume1
    Issue number4
    DOIs
    Publication statusPublished - 2000

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