The cell biology of late blight disease

Stephen C. Whisson; Petra C. Boevink; Shumei Wang; Paul R. J. Birch

doi:10.1016/j.mib.2016.09.002

The cell biology of late blight disease

Stephen C. Whisson, Petra C. Boevink, Shumei Wang, Paul R. J. Birch (Lead / Corresponding author)

Plant Sciences

Research output: Contribution to journal › Article › peer-review

105 Citations (Scopus)

334 Downloads (Pure)

Abstract

Late blight, caused by the oomycete Phytophthora infestans, is a major global disease of potato and tomato. Cell biology is teaching us much about the developmental stages associated with infection, especially the haustorium, which is a site of intimate interaction and molecular exchange between pathogen and host. Recent observations suggest a role for the plant endocytic cycle in specific recruitment of host proteins to the Extra-Haustorial Membrane, emphasising the unique nature of this membrane compartment. In addition, there has been a strong focus on the activities of RXLR effectors, which are delivered into plant cells to modulate and manipulate host processes. RXLR effectors interact directly with diverse plant proteins at a range of subcellular locations to promote disease.

Original language	English
Pages (from-to)	127-135
Number of pages	9
Journal	Current Opinion in Microbiology
Volume	34
Early online date	7 Oct 2016
DOIs	https://doi.org/10.1016/j.mib.2016.09.002
Publication status	Published - Dec 2016

Access to Document

10.1016/j.mib.2016.09.002Licence: CC BY

Final Published Version
© 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Final published version, 864 KBLicence: CC BY

Undermining Effector-Targeted Susceptibility Factors to Provide Late Blight Resistance (Industrial Partnership award)
Birch, P. (Investigator)
Biotechnology and Biological Sciences Research Council
1/04/16 → 31/10/19
Project: Research
UK-China Partnership to Develop Durable Late Blight Disease Resistance in Potato (Partnering Award)
Birch, P. (Investigator)
Biotechnology and Biological Sciences Research Council
1/05/14 → 30/04/17
Project: Research
The Contribution of Phytophthora Effectors to Host Range and Non-Host Resistance (Joint with James Hutton Institute and University of Warwick and Industrial Partners)
Birch, P. (Investigator) & Huitema, E. (Investigator)
Biotechnology and Biological Sciences Research Council
1/08/13 → 12/04/17
Project: Research

Secretion and delivery of virulence proteins from Phytophthora infestans to its host
Wang, S. (Author), Birch, P. (Supervisor), Boevink, P. (Supervisor) & Whisson, S. (Supervisor), 2019
Student thesis: Doctoral Thesis › Doctor of Philosophy

Cite this

@article{3a6de540b7b0424ba677d32a7604a10e,

title = "The cell biology of late blight disease",

abstract = "Late blight, caused by the oomycete Phytophthora infestans, is a major global disease of potato and tomato. Cell biology is teaching us much about the developmental stages associated with infection, especially the haustorium, which is a site of intimate interaction and molecular exchange between pathogen and host. Recent observations suggest a role for the plant endocytic cycle in specific recruitment of host proteins to the Extra-Haustorial Membrane, emphasising the unique nature of this membrane compartment. In addition, there has been a strong focus on the activities of RXLR effectors, which are delivered into plant cells to modulate and manipulate host processes. RXLR effectors interact directly with diverse plant proteins at a range of subcellular locations to promote disease. ",

author = "Whisson, {Stephen C.} and Boevink, {Petra C.} and Shumei Wang and Birch, {Paul R. J.}",

note = "This work was funded by the Scottish Government Rural & Environment Science & Analytical Services Division (RESAS), and the Biotechnology and Biological Sciences Research Council (BBSRC:projects BB/G015244/1, BB/K018183/1, BB/L026880/1). PhD student Shumei Wang is supported by funding from the China Scholarship Council (CSC).",

year = "2016",

month = dec,

doi = "10.1016/j.mib.2016.09.002",

language = "English",

volume = "34",

pages = "127--135",

journal = "Current Opinion in Microbiology",

issn = "1369-5274",

publisher = "Elsevier",

}

TY - JOUR

T1 - The cell biology of late blight disease

AU - Whisson, Stephen C.

AU - Boevink, Petra C.

AU - Wang, Shumei

AU - Birch, Paul R. J.

N1 - This work was funded by the Scottish Government Rural & Environment Science & Analytical Services Division (RESAS), and the Biotechnology and Biological Sciences Research Council (BBSRC:projects BB/G015244/1, BB/K018183/1, BB/L026880/1). PhD student Shumei Wang is supported by funding from the China Scholarship Council (CSC).

PY - 2016/12

Y1 - 2016/12

N2 - Late blight, caused by the oomycete Phytophthora infestans, is a major global disease of potato and tomato. Cell biology is teaching us much about the developmental stages associated with infection, especially the haustorium, which is a site of intimate interaction and molecular exchange between pathogen and host. Recent observations suggest a role for the plant endocytic cycle in specific recruitment of host proteins to the Extra-Haustorial Membrane, emphasising the unique nature of this membrane compartment. In addition, there has been a strong focus on the activities of RXLR effectors, which are delivered into plant cells to modulate and manipulate host processes. RXLR effectors interact directly with diverse plant proteins at a range of subcellular locations to promote disease.

AB - Late blight, caused by the oomycete Phytophthora infestans, is a major global disease of potato and tomato. Cell biology is teaching us much about the developmental stages associated with infection, especially the haustorium, which is a site of intimate interaction and molecular exchange between pathogen and host. Recent observations suggest a role for the plant endocytic cycle in specific recruitment of host proteins to the Extra-Haustorial Membrane, emphasising the unique nature of this membrane compartment. In addition, there has been a strong focus on the activities of RXLR effectors, which are delivered into plant cells to modulate and manipulate host processes. RXLR effectors interact directly with diverse plant proteins at a range of subcellular locations to promote disease.

U2 - 10.1016/j.mib.2016.09.002

DO - 10.1016/j.mib.2016.09.002

M3 - Article

C2 - 27723513

SN - 1369-5274

VL - 34

SP - 127

EP - 135

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

ER -

The cell biology of late blight disease

Abstract

Access to Document

Fingerprint

Undermining Effector-Targeted Susceptibility Factors to Provide Late Blight Resistance (Industrial Partnership award)

UK-China Partnership to Develop Durable Late Blight Disease Resistance in Potato (Partnering Award)

The Contribution of Phytophthora Effectors to Host Range and Non-Host Resistance (Joint with James Hutton Institute and University of Warwick and Industrial Partners)

Secretion and delivery of virulence proteins from Phytophthora infestans to its host

Cite this

The cell biology of late blight disease

Abstract

Access to Document

Fingerprint

Projects

Undermining Effector-Targeted Susceptibility Factors to Provide Late Blight Resistance (Industrial Partnership award)

UK-China Partnership to Develop Durable Late Blight Disease Resistance in Potato (Partnering Award)

The Contribution of Phytophthora Effectors to Host Range and Non-Host Resistance (Joint with James Hutton Institute and University of Warwick and Industrial Partners)

Student theses

Secretion and delivery of virulence proteins from Phytophthora infestans to its host

Cite this