Keyphrases
Cell Permeable
100%
Systemic Sclerosis
100%
Immunomodulatory
100%
Antifibrotic
100%
Itaconate
100%
Dimethyl Itaconate
100%
Nuclear Factor Erythroid 2-related Factor 2 (Nrf2)
45%
Collagen
36%
Dermal Fibroblasts
27%
Gene Expression
18%
Transforming Growth factor-β1 (TGF-β1)
18%
Mediating Effect
9%
Interleukin-6
9%
Inflammatory Cytokines
9%
Incubation
9%
Therapeutic Potential
9%
Reactive Oxygen Species
9%
Antioxidant Response Element
9%
Mouse Embryonic Fibroblasts
9%
Heme oxygenase-1 (HO-1)
9%
NAD(P)
9%
Immunomodulator
9%
Autoimmune Disease
9%
Potential Therapeutics
9%
Reactive Oxygen Species Production
9%
Monocyte Chemoattractant protein-1 (MCP-1)
9%
CCN2
9%
Inflammatory Cytokine Response
9%
Altered Metabolism
9%
Cis-aconitate
9%
Nrf2 Knockout Mice
9%
Quinone Oxidoreductase 1
9%
Krebs Cycle Intermediates
9%
Autoimmune Connective Tissue Diseases
9%
Skin Fibrosis
9%
Intractable Disease
9%
Immunology and Microbiology
Transcription Factor Nrf2
100%
Metabolite
100%
Systemic Scleroderma
100%
Fibroblast
66%
Gene Expression
33%
Transforming Growth Factor Beta1
33%
Wild Type
16%
Interleukin 6
16%
Proinflammatory Cytokine
16%
Upregulation
16%
Inflammatory Cytokine
16%
Knockout Mouse
16%
Antioxidant Responsive Element
16%
Immunomodulating Drugs
16%
Autoimmune Disease
16%
Monocyte Chemotactic Protein 1
16%
Connective Tissue
16%
Cytokine Release
16%
Citric Acid Cycle
16%
Heme
16%
Biochemistry, Genetics and Molecular Biology
Metabolite
100%
Transcription Factor Nrf2
100%
Fibroblast
66%
Gene Expression
33%
TGF Beta 1
33%
Wild Type
16%
Interleukin 6
16%
Metabolic Pathway
16%
Proinflammatory Cytokine
16%
Synapsin I
16%
Upregulation
16%
Knockout Mouse
16%
Oxidoreductase
16%
Antioxidant Responsive Element
16%
Heme Oxygenase
16%
Citric Acid Cycle
16%
Inflammatory Cytokine
16%
Cytokine Release
16%
Medicine and Dentistry
Metabolite
100%
Systemic Scleroderma
100%
Itaconic Acid
100%
Transcription Factor Nrf2
40%
Fibroblast
26%
Gene Expression
13%
Inflammatory Cytokine
13%
Reactive Oxygen Species
13%
Transforming Growth Factor Beta1
13%
Disease
6%
Incubation
6%
Reduced Nicotinamide Adenine Dinucleotide (Phosphate) Dehydrogenase (Quinone)
6%
Heme Oxygenase 1
6%
Citric Acid Cycle
6%
Immunomodulating Agent
6%
Autoimmune Disease
6%
Upregulation
6%
Antioxidant Responsive Element
6%
Connective Tissue Disease
6%
Interleukin 6
6%
Prothrombin
6%
Monocyte Chemotactic Protein 1
6%
Cytokine Release
6%
Aconitic Acid
6%
Skin Fibrosis
6%
Pharmacology, Toxicology and Pharmaceutical Science
Systemic Sclerosis
100%
Itaconic Acid
100%
Transcription Factor Nrf2
40%
Cytokine
13%
Reactive Oxygen Metabolite
13%
Transforming Growth Factor Beta1
13%
Disease
6%
Interleukin 6
6%
Antioxidant
6%
Knockout Mouse
6%
Prothrombin
6%
Reduced Nicotinamide Adenine Dinucleotide (Phosphate) Dehydrogenase (Quinone)
6%
Immunomodulating Agent
6%
Heme Oxygenase 1
6%
Autoimmune Disease
6%
Connective Tissue Disease
6%
Monocyte Chemotactic Protein 1
6%
Aconitic Acid
6%
Skin Fibrosis
6%