The cellular basis of Dictyostelium morphogenesis

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    One of the central aims of the study of development is to understand how distinct cellular behaviours, for example, division, differentiation, apoptosis, and movement, are coordinated in space and in time to result in reproducible pattern formation and morphogenesis. Coordination of these cellular behaviours requires extensive communication between cells of different types and between the cells and their environment. The social amoeba Dictyostelium discoideum, a simple genetically tractable organism situated at the threshold of single and multicellular organisms in the evolutionary tree of life, is well suited for the study of these interactions because its genome has been sequenced and it is amenable to experimental manipulation through targeted gene disruption and replacement (Kreppel, Fey et al. 2004; Eichinger, Pachebat et al. 2005). Dictyostelium cells normally live as single cells in the leaf litter of the soil where they feed on bacteria and divide by binary fission. Under starvation conditions, up to several hundred thousand cells aggregate chemotactically to form a multicellular structure the slug, that directed by light and temperature gradients migrates to the surface of the soil to form a fruiting body. The fruiting body is composed of a stalk supporting a mass of spores. The spores are a dormant stage which after dispersal may germinate to release amoebae, thus closing the life cycle (Fig. 1). We describe here key aspects of the signalling mechanisms coordinating cellular behaviours responsible for pattern formation and morphogenesis.
    Original languageEnglish
    Title of host publicationSystems biology
    Subtitle of host publicationthe challenge of complexity
    EditorsShigetada Nakanishi, Ryoichiro Kageyama, Dai Watanabe
    Place of PublicationBerlin
    PublisherSpringer
    Pages209-220
    Number of pages12
    ISBN (Electronic)9784431877042
    ISBN (Print)9784431877035
    DOIs
    Publication statusPublished - 2009
    EventUehara Memorial Symposium, Systems Biology: The Challenge of Complexity - Tokyo, Japan
    Duration: 30 Jun 20082 Jul 2008

    Conference

    ConferenceUehara Memorial Symposium, Systems Biology: The Challenge of Complexity
    CountryJapan
    CityTokyo
    Period30/06/082/07/08

    Keywords

    • Discoideum mound formation
    • In-situ hybridization
    • Myosin-II
    • Gene expression
    • Nuclear translocation
    • Pattern formation
    • Prespore cells
    • Slug migration
    • STAT protein
    • Social amebas

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