The cellular microscopy phenotype ontology

Simon Jupp (Lead / Corresponding author), James Malone, Tony Burdett, Jean-Karim Heriche, Eleanor Williams, Jan Ellenberg, Helen Parkinson, Gabriella Rustici

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Phenotypic data derived from high content screening is currently annotated using free-text, thus preventing the integration of independent datasets, including those generated in different biological domains, such as cell lines, mouse and human tissues.

DESCRIPTION: We present the Cellular Microscopy Phenotype Ontology (CMPO), a species neutral ontology for describing phenotypic observations relating to the whole cell, cellular components, cellular processes and cell populations. CMPO is compatible with related ontology efforts, allowing for future cross-species integration of phenotypic data. CMPO was developed following a curator-driven approach where phenotype data were annotated by expert biologists following the Entity-Quality (EQ) pattern. These EQs were subsequently transformed into new CMPO terms following an established post composition process.

CONCLUSION: CMPO is currently being utilized to annotate phenotypes associated with high content screening datasets stored in several image repositories including the Image Data Repository (IDR), MitoSys project database and the Cellular Phenotype Database to facilitate data browsing and discoverability.

Original languageEnglish
Article number28
Number of pages8
JournalJournal of Biomedical Semantics
Volume7
DOIs
Publication statusPublished - 18 May 2016

Keywords

  • Ontology
  • OWL
  • Cellular phenotype
  • Imaging

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    Jupp, S., Malone, J., Burdett, T., Heriche, J-K., Williams, E., Ellenberg, J., Parkinson, H., & Rustici, G. (2016). The cellular microscopy phenotype ontology. Journal of Biomedical Semantics, 7, [28]. https://doi.org/10.1186/s13326-016-0074-0