The changing epidemiology of TB disease 2016 – 2018 in a low incidence scottish health board: possible implications for TB elimination

Benedict Warner, Morven Wilkie, Margaret Ramsey, Daniel Chandler, David Connell

    Research output: Contribution to journalMeeting abstract

    Abstract

    Introduction: TB incidence in the UK is falling,1 and elimination may now be a realistic goal in line with the WHO End TB Strategy. In Scotland, numbers of cases are declining but anecdotally are becoming more complex, with implications for the approach to elimination in low-incidence environments.2 NHS Tayside is a low-incidence health board (3.6 per 100,000), with a socially-deprived urban centre, and a large rural population. Changes in TB epidemiology in Tayside were explored from 2016–2018, to assess if this anecdotal change in disease presentation was reflected in real-life practice.

    Method: Data for all cases in Tayside from January’16 to June’18 were obtained from Health Protection Scotland and local Enhanced Surveillance of Mycobacterial Infections and Cohort Review forms. Demographic and clinical details including country of birth, site of disease, and sputum smear status, were recorded.

    Results: Since 2016, the number of cases diagnosed in Tayside has risen from 3 in January-June 2016, to 12 in January-June 2018. In 2016 the majority of cases were extra-pulmonary (66%), however by 2018, 67% were pulmonary TB (figure 1). More recently, the proportion of UK born patients is increasing in Tayside (33% in January-June’16, 60% in January-June’18).

    The average time from symptom onset to treatment (in active pulmonary cases) was 117 days (compared to Key Performance Indicator of 2 months), and from diagnosis to treatment was 10.54 days (compared to KPI of 7 days).

    Conclusions: In the last six months, there appears to have been an increase in the proportion of patients who are UK born. In a low-incidence setting, the epidemiology of TB may be changing to one where cases are harder to manage and diagnose, but may represent more of a threat to ongoing transmission, given the rising proportion of pulmonary TB. Overall this may have implications for future service planning and TB transmission control strategies.

    References

    Thomas HL, et al. Reduction in tuberculosis incidence in the UK from 2011 to 2015: A population-based study. Thorax2018;73:769–75.

    TB Framework for Scotland. Scottish TB network, on behalf of the Scottish GovernmentOctober 2017.
    Original languageEnglish
    Article numberP211
    Pages (from-to)A215-A216
    Number of pages2
    JournalThorax
    Volume73
    Issue numberSupplement 4
    Early online date16 Nov 2018
    DOIs
    Publication statusPublished - Dec 2018
    EventBritish Thoracic Society Winter Meeting 2018 - Queen Elizabeth II Centre, London, United Kingdom
    Duration: 5 Dec 20187 Dec 2018

    Fingerprint

    Epidemiology
    Scotland
    Incidence
    Health
    Lung
    Accidental Falls
    Rural Population
    Sputum
    Tuberculosis
    Demography
    Parturition
    Therapeutics
    Infection
    Population

    Cite this

    Warner, Benedict ; Wilkie, Morven ; Ramsey, Margaret ; Chandler, Daniel ; Connell, David. / The changing epidemiology of TB disease 2016 – 2018 in a low incidence scottish health board : possible implications for TB elimination. In: Thorax. 2018 ; Vol. 73, No. Supplement 4. pp. A215-A216.
    @article{446f4ee15f3a46008a242d5f96d9e4cd,
    title = "The changing epidemiology of TB disease 2016 – 2018 in a low incidence scottish health board: possible implications for TB elimination",
    abstract = "Introduction: TB incidence in the UK is falling,1 and elimination may now be a realistic goal in line with the WHO End TB Strategy. In Scotland, numbers of cases are declining but anecdotally are becoming more complex, with implications for the approach to elimination in low-incidence environments.2 NHS Tayside is a low-incidence health board (3.6 per 100,000), with a socially-deprived urban centre, and a large rural population. Changes in TB epidemiology in Tayside were explored from 2016–2018, to assess if this anecdotal change in disease presentation was reflected in real-life practice.Method: Data for all cases in Tayside from January’16 to June’18 were obtained from Health Protection Scotland and local Enhanced Surveillance of Mycobacterial Infections and Cohort Review forms. Demographic and clinical details including country of birth, site of disease, and sputum smear status, were recorded.Results: Since 2016, the number of cases diagnosed in Tayside has risen from 3 in January-June 2016, to 12 in January-June 2018. In 2016 the majority of cases were extra-pulmonary (66{\%}), however by 2018, 67{\%} were pulmonary TB (figure 1). More recently, the proportion of UK born patients is increasing in Tayside (33{\%} in January-June’16, 60{\%} in January-June’18).The average time from symptom onset to treatment (in active pulmonary cases) was 117 days (compared to Key Performance Indicator of 2 months), and from diagnosis to treatment was 10.54 days (compared to KPI of 7 days).Conclusions: In the last six months, there appears to have been an increase in the proportion of patients who are UK born. In a low-incidence setting, the epidemiology of TB may be changing to one where cases are harder to manage and diagnose, but may represent more of a threat to ongoing transmission, given the rising proportion of pulmonary TB. Overall this may have implications for future service planning and TB transmission control strategies.ReferencesThomas HL, et al. Reduction in tuberculosis incidence in the UK from 2011 to 2015: A population-based study. Thorax2018;73:769–75.TB Framework for Scotland. Scottish TB network, on behalf of the Scottish GovernmentOctober 2017.",
    author = "Benedict Warner and Morven Wilkie and Margaret Ramsey and Daniel Chandler and David Connell",
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    The changing epidemiology of TB disease 2016 – 2018 in a low incidence scottish health board : possible implications for TB elimination. / Warner, Benedict; Wilkie, Morven; Ramsey, Margaret; Chandler, Daniel; Connell, David.

    In: Thorax, Vol. 73, No. Supplement 4, P211, 12.2018, p. A215-A216.

    Research output: Contribution to journalMeeting abstract

    TY - JOUR

    T1 - The changing epidemiology of TB disease 2016 – 2018 in a low incidence scottish health board

    T2 - possible implications for TB elimination

    AU - Warner, Benedict

    AU - Wilkie, Morven

    AU - Ramsey, Margaret

    AU - Chandler, Daniel

    AU - Connell, David

    PY - 2018/12

    Y1 - 2018/12

    N2 - Introduction: TB incidence in the UK is falling,1 and elimination may now be a realistic goal in line with the WHO End TB Strategy. In Scotland, numbers of cases are declining but anecdotally are becoming more complex, with implications for the approach to elimination in low-incidence environments.2 NHS Tayside is a low-incidence health board (3.6 per 100,000), with a socially-deprived urban centre, and a large rural population. Changes in TB epidemiology in Tayside were explored from 2016–2018, to assess if this anecdotal change in disease presentation was reflected in real-life practice.Method: Data for all cases in Tayside from January’16 to June’18 were obtained from Health Protection Scotland and local Enhanced Surveillance of Mycobacterial Infections and Cohort Review forms. Demographic and clinical details including country of birth, site of disease, and sputum smear status, were recorded.Results: Since 2016, the number of cases diagnosed in Tayside has risen from 3 in January-June 2016, to 12 in January-June 2018. In 2016 the majority of cases were extra-pulmonary (66%), however by 2018, 67% were pulmonary TB (figure 1). More recently, the proportion of UK born patients is increasing in Tayside (33% in January-June’16, 60% in January-June’18).The average time from symptom onset to treatment (in active pulmonary cases) was 117 days (compared to Key Performance Indicator of 2 months), and from diagnosis to treatment was 10.54 days (compared to KPI of 7 days).Conclusions: In the last six months, there appears to have been an increase in the proportion of patients who are UK born. In a low-incidence setting, the epidemiology of TB may be changing to one where cases are harder to manage and diagnose, but may represent more of a threat to ongoing transmission, given the rising proportion of pulmonary TB. Overall this may have implications for future service planning and TB transmission control strategies.ReferencesThomas HL, et al. Reduction in tuberculosis incidence in the UK from 2011 to 2015: A population-based study. Thorax2018;73:769–75.TB Framework for Scotland. Scottish TB network, on behalf of the Scottish GovernmentOctober 2017.

    AB - Introduction: TB incidence in the UK is falling,1 and elimination may now be a realistic goal in line with the WHO End TB Strategy. In Scotland, numbers of cases are declining but anecdotally are becoming more complex, with implications for the approach to elimination in low-incidence environments.2 NHS Tayside is a low-incidence health board (3.6 per 100,000), with a socially-deprived urban centre, and a large rural population. Changes in TB epidemiology in Tayside were explored from 2016–2018, to assess if this anecdotal change in disease presentation was reflected in real-life practice.Method: Data for all cases in Tayside from January’16 to June’18 were obtained from Health Protection Scotland and local Enhanced Surveillance of Mycobacterial Infections and Cohort Review forms. Demographic and clinical details including country of birth, site of disease, and sputum smear status, were recorded.Results: Since 2016, the number of cases diagnosed in Tayside has risen from 3 in January-June 2016, to 12 in January-June 2018. In 2016 the majority of cases were extra-pulmonary (66%), however by 2018, 67% were pulmonary TB (figure 1). More recently, the proportion of UK born patients is increasing in Tayside (33% in January-June’16, 60% in January-June’18).The average time from symptom onset to treatment (in active pulmonary cases) was 117 days (compared to Key Performance Indicator of 2 months), and from diagnosis to treatment was 10.54 days (compared to KPI of 7 days).Conclusions: In the last six months, there appears to have been an increase in the proportion of patients who are UK born. In a low-incidence setting, the epidemiology of TB may be changing to one where cases are harder to manage and diagnose, but may represent more of a threat to ongoing transmission, given the rising proportion of pulmonary TB. Overall this may have implications for future service planning and TB transmission control strategies.ReferencesThomas HL, et al. Reduction in tuberculosis incidence in the UK from 2011 to 2015: A population-based study. Thorax2018;73:769–75.TB Framework for Scotland. Scottish TB network, on behalf of the Scottish GovernmentOctober 2017.

    U2 - 10.1136/thorax-2018-212555.368

    DO - 10.1136/thorax-2018-212555.368

    M3 - Meeting abstract

    VL - 73

    SP - A215-A216

    JO - Thorax

    JF - Thorax

    SN - 0040-6376

    IS - Supplement 4

    M1 - P211

    ER -