The characteristics of erythema induced by topical 5-aminolaevulinic acid photodynamic therapy

Colin Clark, Robert S. Dawe, Harry Moseley, James Ferguson, Sally H. Ibbotson

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)

    Abstract

    Background: Topical photodynamic therapy (PDT) is increasingly used to treat superficial non-melanoma skin cancers. Knowledge of the characteristics of
    5-aminolaevulinic acid (ALA)-induced phototoxicity will increase our understanding of PDT and may facilitate optimisation of treatment regimes.
    Methods: We examined the characteristics of ALA-induced erythema in 10 healthy subjects and investigated the effect of light source and body site.
    Results and Conclusion: Maximal erythema occurred within 1–2h of PDT and inter-individual variation in ALA-induced phototoxicity was seen. No detectable
    differences were seen in the phototoxicity on back or leg sites or between coherent and non-coherent light sources. These data provide further information to
    allow us to optimise topical PDT regimes.
    Original languageEnglish
    Pages (from-to)105-107
    Number of pages3
    JournalPhotodermatology, Photoimmunology & Photomedicine
    Volume20
    Issue number2
    DOIs
    Publication statusPublished - Apr 2004

    Keywords

    • Microscopy, Fluorescence
    • Photosensitizing Agents
    • Erythema
    • Humans
    • Photochemotherapy
    • Statistics, Nonparametric
    • Aminolevulinic Acid

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