Abstract
Background: Topical photodynamic therapy (PDT) is increasingly used to treat superficial non-melanoma skin cancers. Knowledge of the characteristics of
5-aminolaevulinic acid (ALA)-induced phototoxicity will increase our understanding of PDT and may facilitate optimisation of treatment regimes.
Methods: We examined the characteristics of ALA-induced erythema in 10 healthy subjects and investigated the effect of light source and body site.
Results and Conclusion: Maximal erythema occurred within 1–2h of PDT and inter-individual variation in ALA-induced phototoxicity was seen. No detectable
differences were seen in the phototoxicity on back or leg sites or between coherent and non-coherent light sources. These data provide further information to
allow us to optimise topical PDT regimes.
5-aminolaevulinic acid (ALA)-induced phototoxicity will increase our understanding of PDT and may facilitate optimisation of treatment regimes.
Methods: We examined the characteristics of ALA-induced erythema in 10 healthy subjects and investigated the effect of light source and body site.
Results and Conclusion: Maximal erythema occurred within 1–2h of PDT and inter-individual variation in ALA-induced phototoxicity was seen. No detectable
differences were seen in the phototoxicity on back or leg sites or between coherent and non-coherent light sources. These data provide further information to
allow us to optimise topical PDT regimes.
| Original language | English |
|---|---|
| Pages (from-to) | 105-107 |
| Number of pages | 3 |
| Journal | Photodermatology, Photoimmunology & Photomedicine |
| Volume | 20 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 2004 |
Keywords
- Microscopy, Fluorescence
- Photosensitizing Agents
- Erythema
- Humans
- Photochemotherapy
- Statistics, Nonparametric
- Aminolevulinic Acid
