The characteristics of erythema induced by topical 5-aminolaevulinic acid photodynamic therapy

Colin Clark; Robert S. Dawe; Harry Moseley; James Ferguson; Sally H. Ibbotson

doi:10.1111/j.1600-0781.2004.00085.x

The characteristics of erythema induced by topical 5-aminolaevulinic acid photodynamic therapy

Colin Clark
, Robert S. Dawe
, Harry Moseley
, James Ferguson
, Sally H. Ibbotson

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Background: Topical photodynamic therapy (PDT) is increasingly used to treat superficial non-melanoma skin cancers. Knowledge of the characteristics of
5-aminolaevulinic acid (ALA)-induced phototoxicity will increase our understanding of PDT and may facilitate optimisation of treatment regimes.
Methods: We examined the characteristics of ALA-induced erythema in 10 healthy subjects and investigated the effect of light source and body site.
Results and Conclusion: Maximal erythema occurred within 1–2h of PDT and inter-individual variation in ALA-induced phototoxicity was seen. No detectable
differences were seen in the phototoxicity on back or leg sites or between coherent and non-coherent light sources. These data provide further information to
allow us to optimise topical PDT regimes.

Original language	English
Pages (from-to)	105-107
Number of pages	3
Journal	Photodermatology, Photoimmunology & Photomedicine
Volume	20
Issue number	2
DOIs	https://doi.org/10.1111/j.1600-0781.2004.00085.x
Publication status	Published - Apr 2004

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Microscopy, Fluorescence
Photosensitizing Agents
Erythema
Humans
Photochemotherapy
Statistics, Nonparametric
Aminolevulinic Acid

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10.1111/j.1600-0781.2004.00085.x

http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291600-0781

Cite this

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title = "The characteristics of erythema induced by topical 5-aminolaevulinic acid photodynamic therapy",

abstract = "Background: Topical photodynamic therapy (PDT) is increasingly used to treat superficial non-melanoma skin cancers. Knowledge of the characteristics of 5-aminolaevulinic acid (ALA)-induced phototoxicity will increase our understanding of PDT and may facilitate optimisation of treatment regimes. Methods: We examined the characteristics of ALA-induced erythema in 10 healthy subjects and investigated the effect of light source and body site. Results and Conclusion: Maximal erythema occurred within 1–2h of PDT and inter-individual variation in ALA-induced phototoxicity was seen. No detectable differences were seen in the phototoxicity on back or leg sites or between coherent and non-coherent light sources. These data provide further information to allow us to optimise topical PDT regimes.",

keywords = "Microscopy, Fluorescence, Photosensitizing Agents, Erythema, Humans, Photochemotherapy, Statistics, Nonparametric, Aminolevulinic Acid",

author = "Colin Clark and Dawe, \{Robert S.\} and Harry Moseley and James Ferguson and Ibbotson, \{Sally H.\}",

year = "2004",

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doi = "10.1111/j.1600-0781.2004.00085.x",

language = "English",

volume = "20",

pages = "105--107",

journal = "Photodermatology, Photoimmunology \& Photomedicine",

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publisher = "Blackwell Munksgaard",

number = "2",

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TY - JOUR

T1 - The characteristics of erythema induced by topical 5-aminolaevulinic acid photodynamic therapy

AU - Clark, Colin

AU - Dawe, Robert S.

AU - Moseley, Harry

AU - Ferguson, James

AU - Ibbotson, Sally H.

PY - 2004/4

Y1 - 2004/4

N2 - Background: Topical photodynamic therapy (PDT) is increasingly used to treat superficial non-melanoma skin cancers. Knowledge of the characteristics of 5-aminolaevulinic acid (ALA)-induced phototoxicity will increase our understanding of PDT and may facilitate optimisation of treatment regimes. Methods: We examined the characteristics of ALA-induced erythema in 10 healthy subjects and investigated the effect of light source and body site. Results and Conclusion: Maximal erythema occurred within 1–2h of PDT and inter-individual variation in ALA-induced phototoxicity was seen. No detectable differences were seen in the phototoxicity on back or leg sites or between coherent and non-coherent light sources. These data provide further information to allow us to optimise topical PDT regimes.

AB - Background: Topical photodynamic therapy (PDT) is increasingly used to treat superficial non-melanoma skin cancers. Knowledge of the characteristics of 5-aminolaevulinic acid (ALA)-induced phototoxicity will increase our understanding of PDT and may facilitate optimisation of treatment regimes. Methods: We examined the characteristics of ALA-induced erythema in 10 healthy subjects and investigated the effect of light source and body site. Results and Conclusion: Maximal erythema occurred within 1–2h of PDT and inter-individual variation in ALA-induced phototoxicity was seen. No detectable differences were seen in the phototoxicity on back or leg sites or between coherent and non-coherent light sources. These data provide further information to allow us to optimise topical PDT regimes.

KW - Microscopy, Fluorescence

KW - Photosensitizing Agents

KW - Erythema

KW - Humans

KW - Photochemotherapy

KW - Statistics, Nonparametric

KW - Aminolevulinic Acid

U2 - 10.1111/j.1600-0781.2004.00085.x

DO - 10.1111/j.1600-0781.2004.00085.x

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JO - Photodermatology, Photoimmunology & Photomedicine

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The characteristics of erythema induced by topical 5-aminolaevulinic acid photodynamic therapy

Abstract

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Keywords

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