The chemical synthesis of bioactive glycosylphosphatidylinositols from Trypanosoma cruzi containing an unsaturated fatty acid in the lipid

Dmitry V. Yashunsky, Vladimir S. Borodkin, Michael A. J. Ferguson, Andrei V. Nikolaev

    Research output: Contribution to journalArticlepeer-review

    48 Citations (Scopus)

    Abstract

    NOTE: THE SPECIAL CHARACTERS IN THIS ABSTRACT CANNOT BE DISPLAYED CORRECTLY ON THIS PAGE. PLEASE REFER TO THE PUBLISHER’S WEBSITE FOR AN ACCURATE DISPLAY Protection strategy: Glycosylphosphatidylinositols (GPIs) from the Trypanosoma cruzi parasite (a causative agent of Chagas' disease) that contain an unsaturated fatty acid in the lipid moiety (see partial structure of 1, R=(CH2)7CH CH(CH2)7CH3, and 2, R=(CH2)7CH CHCH2CH CH(CH2)4CH3) were prepared by a strategy that employs non-benzyl-type protecting groups. The synthetic GPIs show similar biological activity to their natural counterparts.
    Original languageEnglish
    Pages (from-to)468-474
    Number of pages7
    JournalAngewandte Chemie International Edition
    Volume45
    Issue number3
    DOIs
    Publication statusPublished - 2006

    Keywords

    • Glycosylphosphatidylinositols

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