TY - JOUR
T1 - The chemical synthesis of bioactive glycosylphosphatidylinositols from Trypanosoma cruzi containing an unsaturated fatty acid in the lipid
AU - Yashunsky, Dmitry V.
AU - Borodkin, Vladimir S.
AU - Ferguson, Michael A. J.
AU - Nikolaev, Andrei V.
N1 - dc.publisher: Wiley-Blackwell
The definitive version is available at www3.interscience.wiley.com
dc.description.sponsorship: Wellcome Trust Grant
067089/Z/02/Z
PY - 2006
Y1 - 2006
N2 - NOTE: THE SPECIAL CHARACTERS IN THIS ABSTRACT CANNOT BE DISPLAYED CORRECTLY ON THIS PAGE. PLEASE REFER TO THE PUBLISHER’S WEBSITE FOR AN ACCURATE DISPLAY Protection strategy: Glycosylphosphatidylinositols (GPIs) from the Trypanosoma cruzi parasite (a causative agent of Chagas' disease) that contain an unsaturated fatty acid in the lipid moiety (see partial structure of 1, R=(CH2)7CH CH(CH2)7CH3, and 2, R=(CH2)7CH CHCH2CH CH(CH2)4CH3) were prepared by a strategy that employs non-benzyl-type protecting groups. The synthetic GPIs show similar biological activity to their natural counterparts.
AB - NOTE: THE SPECIAL CHARACTERS IN THIS ABSTRACT CANNOT BE DISPLAYED CORRECTLY ON THIS PAGE. PLEASE REFER TO THE PUBLISHER’S WEBSITE FOR AN ACCURATE DISPLAY Protection strategy: Glycosylphosphatidylinositols (GPIs) from the Trypanosoma cruzi parasite (a causative agent of Chagas' disease) that contain an unsaturated fatty acid in the lipid moiety (see partial structure of 1, R=(CH2)7CH CH(CH2)7CH3, and 2, R=(CH2)7CH CHCH2CH CH(CH2)4CH3) were prepared by a strategy that employs non-benzyl-type protecting groups. The synthetic GPIs show similar biological activity to their natural counterparts.
KW - Glycosylphosphatidylinositols
U2 - 10.1002/anie.200502779
DO - 10.1002/anie.200502779
M3 - Article
SN - 1433-7851
VL - 45
SP - 468
EP - 474
JO - Angewandte Chemie International Edition
JF - Angewandte Chemie International Edition
IS - 3
ER -
