The chemical synthesis of bioactive glycosylphosphatidylinositols from Trypanosoma cruzi containing an unsaturated fatty acid in the lipid

Dmitry V. Yashunsky; Vladimir S. Borodkin; Michael A. J. Ferguson; Andrei V. Nikolaev

doi:10.1002/anie.200502779

The chemical synthesis of bioactive glycosylphosphatidylinositols from Trypanosoma cruzi containing an unsaturated fatty acid in the lipid

Dmitry V. Yashunsky
, Vladimir S. Borodkin
, Michael A. J. Ferguson
, Andrei V. Nikolaev

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

NOTE: THE SPECIAL CHARACTERS IN THIS ABSTRACT CANNOT BE DISPLAYED CORRECTLY ON THIS PAGE. PLEASE REFER TO THE PUBLISHER’S WEBSITE FOR AN ACCURATE DISPLAY Protection strategy: Glycosylphosphatidylinositols (GPIs) from the Trypanosoma cruzi parasite (a causative agent of Chagas' disease) that contain an unsaturated fatty acid in the lipid moiety (see partial structure of 1, R=(CH2)7CH CH(CH2)7CH3, and 2, R=(CH2)7CH CHCH2CH CH(CH2)4CH3) were prepared by a strategy that employs non-benzyl-type protecting groups. The synthetic GPIs show similar biological activity to their natural counterparts.

Original language	English
Pages (from-to)	468-474
Number of pages	7
Journal	Angewandte Chemie International Edition
Volume	45
Issue number	3
DOIs	https://doi.org/10.1002/anie.200502779
Publication status	Published - 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Glycosylphosphatidylinositols

Access to Document

10.1002/anie.200502779

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title = "The chemical synthesis of bioactive glycosylphosphatidylinositols from Trypanosoma cruzi containing an unsaturated fatty acid in the lipid",

abstract = "NOTE: THE SPECIAL CHARACTERS IN THIS ABSTRACT CANNOT BE DISPLAYED CORRECTLY ON THIS PAGE. PLEASE REFER TO THE PUBLISHER{\textquoteright}S WEBSITE FOR AN ACCURATE DISPLAY Protection strategy: Glycosylphosphatidylinositols (GPIs) from the Trypanosoma cruzi parasite (a causative agent of Chagas' disease) that contain an unsaturated fatty acid in the lipid moiety (see partial structure of 1, R=(CH2)7CH CH(CH2)7CH3, and 2, R=(CH2)7CH CHCH2CH CH(CH2)4CH3) were prepared by a strategy that employs non-benzyl-type protecting groups. The synthetic GPIs show similar biological activity to their natural counterparts.",

keywords = "Glycosylphosphatidylinositols",

author = "Yashunsky, \{Dmitry V.\} and Borodkin, \{Vladimir S.\} and Ferguson, \{Michael A. J.\} and Nikolaev, \{Andrei V.\}",

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year = "2006",

doi = "10.1002/anie.200502779",

language = "English",

volume = "45",

pages = "468--474",

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AU - Yashunsky, Dmitry V.

AU - Borodkin, Vladimir S.

AU - Ferguson, Michael A. J.

AU - Nikolaev, Andrei V.

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PY - 2006

Y1 - 2006

N2 - NOTE: THE SPECIAL CHARACTERS IN THIS ABSTRACT CANNOT BE DISPLAYED CORRECTLY ON THIS PAGE. PLEASE REFER TO THE PUBLISHER’S WEBSITE FOR AN ACCURATE DISPLAY Protection strategy: Glycosylphosphatidylinositols (GPIs) from the Trypanosoma cruzi parasite (a causative agent of Chagas' disease) that contain an unsaturated fatty acid in the lipid moiety (see partial structure of 1, R=(CH2)7CH CH(CH2)7CH3, and 2, R=(CH2)7CH CHCH2CH CH(CH2)4CH3) were prepared by a strategy that employs non-benzyl-type protecting groups. The synthetic GPIs show similar biological activity to their natural counterparts.

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KW - Glycosylphosphatidylinositols

U2 - 10.1002/anie.200502779

DO - 10.1002/anie.200502779

M3 - Article

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IS - 3

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The chemical synthesis of bioactive glycosylphosphatidylinositols from Trypanosoma cruzi containing an unsaturated fatty acid in the lipid

Abstract

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Keywords

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