The chemical synthesis of Leishmania donovani phosphoglycan via polycondensation of a glycobiosyl hydrogenphosphonate monomer

Andrei V. Nikolaev, John Alexander Chudek, Michael A. J. Ferguson

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    45 Citations (Scopus)

    Abstract

    A polycondensation of 2,3,6-tri-O-benzoyl-4-O-(2,3,4-tri-O-benzoyl-ß-D-galactopyranosyl)-a -D-mannopyranosyl hydrogenphosphonate in the presence of trimethylacetyl chloride has been used to synthesize a linear poly[ß-D-galactopyranosyl-(1?4)-a-D-mannopyranosyl phosphate] representing the phosphoglycan part of the lipophosphoglycan from Leishmania donovani.

    Original languageEnglish
    Pages (from-to)179-189
    Number of pages11
    JournalCarbohydrate Research
    Volume272
    Issue number2
    DOIs
    Publication statusPublished - 1 Jan 1995

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