The chemistry of copper binding to PrP: is there sufficient evidence to elucidate a role for copper in protein function?

Paul Davies; David R. Brown

doi:10.1042/bj20071477

The chemistry of copper binding to PrP: is there sufficient evidence to elucidate a role for copper in protein function?

Paul Davies
, David R. Brown (Lead / Corresponding author)

Research output: Contribution to journal › Review article › peer-review

62 Citations (Scopus)

Abstract

There has been an enormous body of literature published in the last 10 years concerning copper and PrP (prion protein). Despite this, there is still no generally accepted role for copper in the function
of PrP or any real consensus as to how and to what affinity copper associates with the protein. The present review attempts to look at all the evidence for the chemistry, co-ordination and affinity of
copper binding to PrP, and then looks at what effect this has on the protein. We then connect this evidence with possible roles for PrP when bound to copper. No clear conclusions can be made from
the available data, but it is clear from the present review what aspects of copper association with PrP need to be re-investigated.

Original language	English
Pages (from-to)	237-244
Number of pages	8
Journal	The Biochemical journal
Volume	410
Issue number	2
Early online date	12 Feb 2008
DOIs	https://doi.org/10.1042/bj20071477
Publication status	E-pub ahead of print - 12 Feb 2008

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10.1042/bj20071477

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title = "The chemistry of copper binding to PrP: is there sufficient evidence to elucidate a role for copper in protein function?",

abstract = "There has been an enormous body of literature published in the last 10 years concerning copper and PrP (prion protein). Despite this, there is still no generally accepted role for copper in the function of PrP or any real consensus as to how and to what affinity copper associates with the protein. The present review attempts to look at all the evidence for the chemistry, co-ordination and affinity of copper binding to PrP, and then looks at what effect this has on the protein. We then connect this evidence with possible roles for PrP when bound to copper. No clear conclusions can be made from the available data, but it is clear from the present review what aspects of copper association with PrP need to be re-investigated.",

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T2 - is there sufficient evidence to elucidate a role for copper in protein function?

AU - Davies, Paul

AU - Brown, David R.

PY - 2008/2/12

Y1 - 2008/2/12

N2 - There has been an enormous body of literature published in the last 10 years concerning copper and PrP (prion protein). Despite this, there is still no generally accepted role for copper in the function of PrP or any real consensus as to how and to what affinity copper associates with the protein. The present review attempts to look at all the evidence for the chemistry, co-ordination and affinity of copper binding to PrP, and then looks at what effect this has on the protein. We then connect this evidence with possible roles for PrP when bound to copper. No clear conclusions can be made from the available data, but it is clear from the present review what aspects of copper association with PrP need to be re-investigated.

AB - There has been an enormous body of literature published in the last 10 years concerning copper and PrP (prion protein). Despite this, there is still no generally accepted role for copper in the function of PrP or any real consensus as to how and to what affinity copper associates with the protein. The present review attempts to look at all the evidence for the chemistry, co-ordination and affinity of copper binding to PrP, and then looks at what effect this has on the protein. We then connect this evidence with possible roles for PrP when bound to copper. No clear conclusions can be made from the available data, but it is clear from the present review what aspects of copper association with PrP need to be re-investigated.

UR - http://europepmc.org/abstract/med/18254729

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DO - 10.1042/bj20071477

M3 - Review article

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SP - 237

EP - 244

JO - The Biochemical journal

JF - The Biochemical journal

IS - 2

ER -

The chemistry of copper binding to PrP: is there sufficient evidence to elucidate a role for copper in protein function?

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