The chromosome cycle

coordinating replication and segregation

    Research output: Contribution to journalArticle

    32 Citations (Scopus)

    Abstract

    During the cell-division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.
    Original languageEnglish
    Pages (from-to)1028-34
    Number of pages7
    JournalEMBO Reports
    Volume6
    Issue number11
    DOIs
    Publication statusPublished - 2005

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    Chromosomes
    Cell Cycle
    DNA
    Licensure
    Cells

    Keywords

    • Cell cycle
    • Cohesion
    • DNA replication
    • Replication licensing

    Cite this

    @article{a14105dbafb8480ba2e9b5525f74cd93,
    title = "The chromosome cycle: coordinating replication and segregation",
    abstract = "During the cell-division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.",
    keywords = "Cell cycle, Cohesion, DNA replication, Replication licensing",
    author = "Blow, {J. Julian} and Tanaka, {Tomoyuki U.}",
    note = "Second in the Cycles review series",
    year = "2005",
    doi = "10.1038/sj.embor.7400557",
    language = "English",
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    pages = "1028--34",
    journal = "EMBO Reports",
    issn = "1469-221X",
    publisher = "EMBO Press",
    number = "11",

    }

    The chromosome cycle : coordinating replication and segregation. / Blow, J. Julian; Tanaka, Tomoyuki U.

    In: EMBO Reports, Vol. 6, No. 11, 2005, p. 1028-34.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - The chromosome cycle

    T2 - coordinating replication and segregation

    AU - Blow, J. Julian

    AU - Tanaka, Tomoyuki U.

    N1 - Second in the Cycles review series

    PY - 2005

    Y1 - 2005

    N2 - During the cell-division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.

    AB - During the cell-division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.

    KW - Cell cycle

    KW - Cohesion

    KW - DNA replication

    KW - Replication licensing

    U2 - 10.1038/sj.embor.7400557

    DO - 10.1038/sj.embor.7400557

    M3 - Article

    VL - 6

    SP - 1028

    EP - 1034

    JO - EMBO Reports

    JF - EMBO Reports

    SN - 1469-221X

    IS - 11

    ER -