The chromosome cycle: coordinating replication and segregation

J. Julian Blow; Tomoyuki U. Tanaka

doi:10.1038/sj.embor.7400557

The chromosome cycle: coordinating replication and segregation

J. Julian Blow, Tomoyuki U. Tanaka

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

During the cell-division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.

Original language	English
Pages (from-to)	1028-34
Number of pages	7
Journal	EMBO Reports
Volume	6
Issue number	11
DOIs	https://doi.org/10.1038/sj.embor.7400557
Publication status	Published - 2005

Keywords

Cell cycle
Cohesion
DNA replication
Replication licensing

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10.1038/sj.embor.7400557

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title = "The chromosome cycle: coordinating replication and segregation",

abstract = "During the cell-division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.",

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AU - Tanaka, Tomoyuki U.

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AB - During the cell-division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.

KW - Cell cycle

KW - Cohesion

KW - DNA replication

KW - Replication licensing

U2 - 10.1038/sj.embor.7400557

DO - 10.1038/sj.embor.7400557

M3 - Article

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SN - 1469-221X

VL - 6

SP - 1028

EP - 1034

JO - EMBO Reports

JF - EMBO Reports

IS - 11

ER -

The chromosome cycle: coordinating replication and segregation

Abstract

Keywords

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