The chromosome cycle: coordinating replication and segregation

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    42 Citations (Scopus)


    During the cell-division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.
    Original languageEnglish
    Pages (from-to)1028-34
    Number of pages7
    JournalEMBO Reports
    Issue number11
    Publication statusPublished - 2005


    • Cell cycle
    • Cohesion
    • DNA replication
    • Replication licensing


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