The colorectal adenoma-carcinoma sequence

A. Leslie, F. A. Carey, N. R. Pratt, R. J. C. Steele

    Research output: Contribution to journalArticlepeer-review

    528 Citations (Scopus)


    It is widely accepted that the adenoma-carcinoma sequence represents the process by which most, if not all, colorectal cancers arise. The evidence supporting this hypothesis has increased rapidly in recent years and the purpose of this article is to review this evidence critically and highlight its clinical significance.
    Original languageEnglish
    Pages (from-to)845-60
    Number of pages16
    JournalBritish Journal of Surgery
    Issue number7
    Publication statusPublished - Jul 2002


    • Adenoma
    • Adenomatous Polyposis Coli Protein
    • Base Pair Mismatch
    • Carcinoma
    • Cell Transformation, Neoplastic
    • Colorectal Neoplasms
    • DNA Methylation
    • DNA Repair
    • Gene Deletion
    • Gene Expression
    • Genes, p53
    • Genes, ras
    • Humans
    • Karyotyping
    • Microsatellite Repeats
    • Mutation


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