The colorectal adenoma-carcinoma sequence

A. Leslie; F. A. Carey; N. R. Pratt; R. J. C. Steele

doi:10.1046/j.1365-2168.2002.02120.x

The colorectal adenoma-carcinoma sequence

A. Leslie, F. A. Carey, N. R. Pratt, R. J. C. Steele

Research output: Contribution to journal › Article › peer-review

546 Citations (Scopus)

Abstract

It is widely accepted that the adenoma-carcinoma sequence represents the process by which most, if not all, colorectal cancers arise. The evidence supporting this hypothesis has increased rapidly in recent years and the purpose of this article is to review this evidence critically and highlight its clinical significance.

Original language	English
Pages (from-to)	845-60
Number of pages	16
Journal	British Journal of Surgery
Volume	89
Issue number	7
DOIs	https://doi.org/10.1046/j.1365-2168.2002.02120.x
Publication status	Published - Jul 2002

Keywords

Adenoma
Adenomatous Polyposis Coli Protein
Base Pair Mismatch
Carcinoma
Cell Transformation, Neoplastic
Colorectal Neoplasms
DNA Methylation
DNA Repair
Gene Deletion
Gene Expression
Genes, p53
Genes, ras
Humans
Karyotyping
Microsatellite Repeats
Mutation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1046/j.1365-2168.2002.02120.x

http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2168.2002.02120.x/abstract;jsessionid=646066CF9977C770126B53A3AA4CBE79.f02t02

Cite this

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title = "The colorectal adenoma-carcinoma sequence",

abstract = "It is widely accepted that the adenoma-carcinoma sequence represents the process by which most, if not all, colorectal cancers arise. The evidence supporting this hypothesis has increased rapidly in recent years and the purpose of this article is to review this evidence critically and highlight its clinical significance.",

keywords = "Adenoma, Adenomatous Polyposis Coli Protein, Base Pair Mismatch, Carcinoma, Cell Transformation, Neoplastic, Colorectal Neoplasms, DNA Methylation, DNA Repair, Gene Deletion, Gene Expression, Genes, p53, Genes, ras, Humans, Karyotyping, Microsatellite Repeats, Mutation",

author = "A. Leslie and Carey, {F. A.} and Pratt, {N. R.} and Steele, {R. J. C.}",

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AU - Leslie, A.

AU - Carey, F. A.

AU - Pratt, N. R.

AU - Steele, R. J. C.

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Y1 - 2002/7

N2 - It is widely accepted that the adenoma-carcinoma sequence represents the process by which most, if not all, colorectal cancers arise. The evidence supporting this hypothesis has increased rapidly in recent years and the purpose of this article is to review this evidence critically and highlight its clinical significance.

AB - It is widely accepted that the adenoma-carcinoma sequence represents the process by which most, if not all, colorectal cancers arise. The evidence supporting this hypothesis has increased rapidly in recent years and the purpose of this article is to review this evidence critically and highlight its clinical significance.

KW - Adenoma

KW - Adenomatous Polyposis Coli Protein

KW - Base Pair Mismatch

KW - Carcinoma

KW - Cell Transformation, Neoplastic

KW - Colorectal Neoplasms

KW - DNA Methylation

KW - DNA Repair

KW - Gene Deletion

KW - Gene Expression

KW - Genes, p53

KW - Genes, ras

KW - Humans

KW - Karyotyping

KW - Microsatellite Repeats

KW - Mutation

U2 - 10.1046/j.1365-2168.2002.02120.x

DO - 10.1046/j.1365-2168.2002.02120.x

M3 - Article

C2 - 12081733

SN - 0007-1323

VL - 89

SP - 845

EP - 860

JO - British Journal of Surgery

JF - British Journal of Surgery

IS - 7

ER -

The colorectal adenoma-carcinoma sequence

Abstract

Keywords

UN SDGs

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