The colorectal adenoma-carcinoma sequence

A. Leslie, F. A. Carey, N. R. Pratt, R. J. C. Steele

    Research output: Contribution to journalArticle

    396 Citations (Scopus)

    Abstract

    It is widely accepted that the adenoma-carcinoma sequence represents the process by which most, if not all, colorectal cancers arise. The evidence supporting this hypothesis has increased rapidly in recent years and the purpose of this article is to review this evidence critically and highlight its clinical significance.
    Original languageEnglish
    Pages (from-to)845-60
    Number of pages16
    JournalBritish Journal of Surgery
    Volume89
    Issue number7
    DOIs
    Publication statusPublished - Jul 2002

    Keywords

    • Adenoma
    • Adenomatous Polyposis Coli Protein
    • Base Pair Mismatch
    • Carcinoma
    • Cell Transformation, Neoplastic
    • Colorectal Neoplasms
    • DNA Methylation
    • DNA Repair
    • Gene Deletion
    • Gene Expression
    • Genes, p53
    • Genes, ras
    • Humans
    • Karyotyping
    • Microsatellite Repeats
    • Mutation

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