The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe

Diego Miranda-Saavedra, Michael J R Stark, Jeremy C Packer, Christian P Vivares, Christian Doerig, Geoffrey J Barton

    Research output: Contribution to journalArticle

    47 Citations (Scopus)

    Abstract

    Microsporidia, parasitic fungi-related eukaryotes infecting many cell types in a wide range of animals (including humans), represent a serious health threat in immunocompromised patients. The 2.9 Mb genome of the microsporidium Encephalitozoon cuniculi is the smallest known of any eukaryote. Eukaryotic protein kinases are a large superfamily of enzymes with crucial roles in most cellular processes, and therefore represent potential drug targets. We report here an exhaustive analysis of the E. cuniculi genomic database aimed at identifying and classifying all protein kinases of this organism with reference to the kinomes of two highly-divergent yeast species, Saccharomyces cerevisiae and Schizosaccharomyces pombe.
    Original languageEnglish
    Article number309
    JournalBMC Genomics
    Volume8
    DOIs
    Publication statusPublished - 2007

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    Unclassified Microsporidia
    Encephalitozoon cuniculi
    Schizosaccharomyces
    Eukaryota
    Protein Kinases
    Saccharomyces cerevisiae
    Complement System Proteins
    Microsporidia
    Immunocompromised Host
    Fungi
    Yeasts
    Genome
    Databases
    Health
    Enzymes
    Pharmaceutical Preparations

    Cite this

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    title = "The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe",
    abstract = "Microsporidia, parasitic fungi-related eukaryotes infecting many cell types in a wide range of animals (including humans), represent a serious health threat in immunocompromised patients. The 2.9 Mb genome of the microsporidium Encephalitozoon cuniculi is the smallest known of any eukaryote. Eukaryotic protein kinases are a large superfamily of enzymes with crucial roles in most cellular processes, and therefore represent potential drug targets. We report here an exhaustive analysis of the E. cuniculi genomic database aimed at identifying and classifying all protein kinases of this organism with reference to the kinomes of two highly-divergent yeast species, Saccharomyces cerevisiae and Schizosaccharomyces pombe.",
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    language = "English",
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    The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe. / Miranda-Saavedra, Diego; Stark, Michael J R; Packer, Jeremy C; Vivares, Christian P; Doerig, Christian; Barton, Geoffrey J.

    In: BMC Genomics, Vol. 8, 309, 2007.

    Research output: Contribution to journalArticle

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    AU - Miranda-Saavedra, Diego

    AU - Stark, Michael J R

    AU - Packer, Jeremy C

    AU - Vivares, Christian P

    AU - Doerig, Christian

    AU - Barton, Geoffrey J

    PY - 2007

    Y1 - 2007

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    AB - Microsporidia, parasitic fungi-related eukaryotes infecting many cell types in a wide range of animals (including humans), represent a serious health threat in immunocompromised patients. The 2.9 Mb genome of the microsporidium Encephalitozoon cuniculi is the smallest known of any eukaryote. Eukaryotic protein kinases are a large superfamily of enzymes with crucial roles in most cellular processes, and therefore represent potential drug targets. We report here an exhaustive analysis of the E. cuniculi genomic database aimed at identifying and classifying all protein kinases of this organism with reference to the kinomes of two highly-divergent yeast species, Saccharomyces cerevisiae and Schizosaccharomyces pombe.

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