Abstract
Sugammadex is the first selective relaxant binding agent. It allows rapid reversal of any degree of neuromuscular blockade induced by steroidal neuromuscular blocking agents. Sugammadex acts by encapsulation of the neuromuscular blocking agent. This prevents the drug from acting on prejunctional and postjunctional nicotinic receptors, allowing acetylcholine to activate these receptors, and resulting in reversal of the neuromuscular blockade. Objective monitoring of the degree of neuromuscular blockade is strongly recommended to determine the optimal dose of sugammadex. A good understanding of the concept behind sugammadex is essential in order to use this reversal agent in clinical practice.
| Original language | English |
|---|---|
| Pages (from-to) | 272-276 |
| Number of pages | 5 |
| Journal | Revista Española de Anestesiología y Reanimación |
| Volume | 61 |
| Issue number | 5 |
| Early online date | 15 Mar 2014 |
| DOIs | |
| Publication status | Published - May 2014 |
Keywords
- Neuromuscular blocking agents
- Rocuronium
- Vecuronium
- Sugammadex
- Reversal
- Pharmacology