The concept behind sugammadex

O. Epemolu (Lead / Corresponding author), A. Bom

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Sugammadex is the first selective relaxant binding agent. It allows rapid reversal of any degree of neuromuscular blockade induced by steroidal neuromuscular blocking agents. Sugammadex acts by encapsulation of the neuromuscular blocking agent. This prevents the drug from acting on prejunctional and postjunctional nicotinic receptors, allowing acetylcholine to activate these receptors, and resulting in reversal of the neuromuscular blockade. Objective monitoring of the degree of neuromuscular blockade is strongly recommended to determine the optimal dose of sugammadex. A good understanding of the concept behind sugammadex is essential in order to use this reversal agent in clinical practice.

Original languageEnglish
Pages (from-to)272-276
Number of pages5
JournalRevista Española de Anestesiología y Reanimación
Volume61
Issue number5
Early online date15 Mar 2014
DOIs
Publication statusPublished - May 2014

Keywords

  • Neuromuscular blocking agents
  • Rocuronium
  • Vecuronium
  • Sugammadex
  • Reversal
  • Pharmacology

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