The contribution of dormant origins to genome stability: from cell biology to human genetics

Robert C. Alver; Gaganmeet Singh Chadha; J. Julian Blow

doi:10.1016/j.dnarep.2014.03.012

The contribution of dormant origins to genome stability: from cell biology to human genetics

Robert C. Alver, Gaganmeet Singh Chadha, J. Julian Blow (Lead / Corresponding author)

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Abstract

The ability of a eukaryotic cell to precisely and accurately replicate its DNA is crucial to maintain genome stability. Here we describe our current understanding of the process by which origins are licensed for DNA replication and review recent work suggesting that fork stalling has exerted a strong selective pressure on the positioning of licensed origins. In light of this, we discuss the complex and disparate phenotypes observed in mouse models and humans patients that arise due to defects in replication licensing proteins.

Original language	English
Pages (from-to)	182-189
Number of pages	8
Journal	DNA Repair
Volume	19
DOIs	https://doi.org/10.1016/j.dnarep.2014.03.012
Publication status	Published - Jul 2014

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10.1016/j.dnarep.2014.03.012

1-s2.0-S1568786414000834-mainFinal published version, 1.5 MB

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abstract = "The ability of a eukaryotic cell to precisely and accurately replicate its DNA is crucial to maintain genome stability. Here we describe our current understanding of the process by which origins are licensed for DNA replication and review recent work suggesting that fork stalling has exerted a strong selective pressure on the positioning of licensed origins. In light of this, we discuss the complex and disparate phenotypes observed in mouse models and humans patients that arise due to defects in replication licensing proteins.",

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The contribution of dormant origins to genome stability: from cell biology to human genetics

Abstract

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Strategic Award: Wellcome Trust Technology Platform

Understanding the Cellular Response to Replication Inhibition (Senior Investigator Award)

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The contribution of dormant origins to genome stability: from cell biology to human genetics

Abstract

Access to Document

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Projects

Strategic Award: Wellcome Trust Technology Platform

Understanding the Cellular Response to Replication Inhibition (Senior Investigator Award)

Cite this