The contribution of dormant origins to genome stability: from cell biology to human genetics

Robert C. Alver, Gaganmeet Singh Chadha, J. Julian Blow (Lead / Corresponding author)

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    Abstract

    The ability of a eukaryotic cell to precisely and accurately replicate its DNA is crucial to maintain genome stability. Here we describe our current understanding of the process by which origins are licensed for DNA replication and review recent work suggesting that fork stalling has exerted a strong selective pressure on the positioning of licensed origins. In light of this, we discuss the complex and disparate phenotypes observed in mouse models and humans patients that arise due to defects in replication licensing proteins.
    Original languageEnglish
    Pages (from-to)182-189
    Number of pages8
    JournalDNA Repair
    Volume19
    DOIs
    Publication statusPublished - Jul 2014

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