The coordination of T-cell function by serine/threonine kinases

David Finlay, Doreen Cantrell

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    The function of T-lymphocytes during adaptive immune responses is directed by antigen receptors, costimulatory molecules, and cytokines. These extrinsic stimuli are coupled to a network of serine/threonine kinases that control the epigenetic, transcriptional, and metabolic programs that determine T-cell function. It is increasingly recognized that serine/threonine kinases, notably those that are controlled by lipid second messengers such as polyunsaturated diacylglycerols (DAG) and phosphatidylinositol-(3,4,5)-trisphosphate (PIP3), are at the core of T-cell signal transduction. In the present review the object will be to discuss some important examples of how pathways of serine/threonine phosphorylation control molecular functions of proteins and control protein localization to coordinate T-cell function in adaptive immune responses.

    Original languageEnglish
    Article numbera002261
    Pages (from-to)-
    Number of pages10
    JournalCold spring harbor perspectives in biology
    Volume3
    Issue number1
    DOIs
    Publication statusPublished - Jan 2011

    Keywords

    • Hydrophobic motif phosphorylation
    • Activated protein-kinase
    • Phosphatidylinositol 3-kinase
    • L-selectin
    • Immunological synapse
    • Histone deacetylases
    • Antigen receptor
    • MTOR complex
    • In vivo
    • Lymphocytes

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