Abstract
The function of T-lymphocytes during adaptive immune responses is directed by antigen receptors, costimulatory molecules, and cytokines. These extrinsic stimuli are coupled to a network of serine/threonine kinases that control the epigenetic, transcriptional, and metabolic programs that determine T-cell function. It is increasingly recognized that serine/threonine kinases, notably those that are controlled by lipid second messengers such as polyunsaturated diacylglycerols (DAG) and phosphatidylinositol-(3,4,5)-trisphosphate (PIP3), are at the core of T-cell signal transduction. In the present review the object will be to discuss some important examples of how pathways of serine/threonine phosphorylation control molecular functions of proteins and control protein localization to coordinate T-cell function in adaptive immune responses.
| Original language | English |
|---|---|
| Article number | a002261 |
| Pages (from-to) | - |
| Number of pages | 10 |
| Journal | Cold spring harbor perspectives in biology |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2011 |
Keywords
- Hydrophobic motif phosphorylation
- Activated protein-kinase
- Phosphatidylinositol 3-kinase
- L-selectin
- Immunological synapse
- Histone deacetylases
- Antigen receptor
- MTOR complex
- In vivo
- Lymphocytes