The copper binding properties of metformin - QCM-D, XPS and nanobead agglomeration

Xueling Quan; Rokon Uddin; Arto Heiskanen; Mattias Parmvi; Katharina Nilson; Marco Donolato; Mikkel F. Hansen; Graham Rena; Anja Boisen

doi:10.1039/c5cc04321b

The copper binding properties of metformin - QCM-D, XPS and nanobead agglomeration

Xueling Quan (Lead / Corresponding author), Rokon Uddin, Arto Heiskanen, Mattias Parmvi, Katharina Nilson, Marco Donolato, Mikkel F. Hansen, Graham Rena, Anja Boisen (Lead / Corresponding author)

Postgraduate Medicine

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Study of the copper binding properties of metformin is important for revealing its mechanism of action as a first-line type-2 diabetes drug. A quantitative investigation of interactions between metformin and l-cysteine-copper complexes was performed. The results suggest that metformin could interact with biological copper, which plays a key role in mitochondrial function.

Original language	English
Pages (from-to)	17313-17316
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	97
DOIs	https://doi.org/10.1039/c5cc04321b
Publication status	Published - 18 Dec 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c5cc04321b

Investigation of the Target of Metformin
Prescott, A. (Investigator) & Rena, G. (Investigator)
Medical Research Council
1/05/13 → 30/04/16
Project: Research

Rena, Graham
- Diabetes Endocrinology and Reproductive Biology - Professor (Teaching and Research) of CARDIOVASCULAR AND METABOLIC MEDICINE
Person: Academic

Cite this

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title = "The copper binding properties of metformin - QCM-D, XPS and nanobead agglomeration",

abstract = "Study of the copper binding properties of metformin is important for revealing its mechanism of action as a first-line type-2 diabetes drug. A quantitative investigation of interactions between metformin and l-cysteine-copper complexes was performed. The results suggest that metformin could interact with biological copper, which plays a key role in mitochondrial function.",

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AU - Quan, Xueling

AU - Uddin, Rokon

AU - Heiskanen, Arto

AU - Parmvi, Mattias

AU - Nilson, Katharina

AU - Donolato, Marco

AU - Hansen, Mikkel F.

AU - Rena, Graham

AU - Boisen, Anja

PY - 2015/12/18

Y1 - 2015/12/18

N2 - Study of the copper binding properties of metformin is important for revealing its mechanism of action as a first-line type-2 diabetes drug. A quantitative investigation of interactions between metformin and l-cysteine-copper complexes was performed. The results suggest that metformin could interact with biological copper, which plays a key role in mitochondrial function.

AB - Study of the copper binding properties of metformin is important for revealing its mechanism of action as a first-line type-2 diabetes drug. A quantitative investigation of interactions between metformin and l-cysteine-copper complexes was performed. The results suggest that metformin could interact with biological copper, which plays a key role in mitochondrial function.

U2 - 10.1039/c5cc04321b

DO - 10.1039/c5cc04321b

M3 - Article

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JO - Chemical Communications

JF - Chemical Communications

IS - 97

ER -

The copper binding properties of metformin - QCM-D, XPS and nanobead agglomeration

Abstract

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Projects

Investigation of the Target of Metformin

Profiles

Rena, Graham

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