The copper binding properties of metformin - QCM-D, XPS and nanobead agglomeration

Xueling Quan (Lead / Corresponding author), Rokon Uddin, Arto Heiskanen, Mattias Parmvi, Katharina Nilson, Marco Donolato, Mikkel F. Hansen, Graham Rena, Anja Boisen (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Study of the copper binding properties of metformin is important for revealing its mechanism of action as a first-line type-2 diabetes drug. A quantitative investigation of interactions between metformin and l-cysteine-copper complexes was performed. The results suggest that metformin could interact with biological copper, which plays a key role in mitochondrial function.

Original languageEnglish
Pages (from-to)17313-17316
Number of pages4
JournalChemical Communications
Volume51
Issue number97
DOIs
Publication statusPublished - 18 Dec 2015

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