The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

Lauren F. Stevenson; Alison Sparks; Nerea Allende-Vega; Dimitris P. Xirodimas; David Lane; Mark K. Saville

doi:doi:10.1038/sj.emboj.7601567

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

Lauren F. Stevenson, Alison Sparks, Nerea Allende-Vega, Dimitris P. Xirodimas, David Lane, Mark K. Saville

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	976-986
Number of pages	11
Journal	The EMBO Journal
Volume	26
Issue number	4
DOIs	https://doi.org/doi:10.1038/sj.emboj.7601567
Publication status	Published - 2007

Keywords

Deubiquitinating enzyme
HAUSP
Mdm2
p53
USP2a

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doi:10.1038/sj.emboj.7601567

Cite this

@article{1b03d7a5a894434eb0e8eea8cadd8c17,

title = "The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2",

keywords = "Deubiquitinating enzyme, HAUSP, Mdm2, p53, USP2a",

author = "Stevenson, {Lauren F.} and Alison Sparks and Nerea Allende-Vega and Xirodimas, {Dimitris P.} and David Lane and Saville, {Mark K.}",

note = "dc.publisher: Nature Publishing Group Senior author of paper describing novel interaction between Mdm2 and the deubiquitinating enzyme USP2a identifying USP2a as a novel regulator of the Mdm2/p53 pathway significantly contributing to p53 activity repression. The study furthers understanding of the complexities of p53 control and identifies USP2a as a novel target for cancer therapy. ",

year = "2007",

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language = "English",

volume = "26",

pages = "976--986",

journal = "The EMBO Journal",

issn = "0261-4189",

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T1 - The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

AU - Stevenson, Lauren F.

AU - Sparks, Alison

AU - Allende-Vega, Nerea

AU - Xirodimas, Dimitris P.

AU - Lane, David

AU - Saville, Mark K.

N1 - dc.publisher: Nature Publishing Group Senior author of paper describing novel interaction between Mdm2 and the deubiquitinating enzyme USP2a identifying USP2a as a novel regulator of the Mdm2/p53 pathway significantly contributing to p53 activity repression. The study furthers understanding of the complexities of p53 control and identifies USP2a as a novel target for cancer therapy.

PY - 2007

Y1 - 2007

KW - Deubiquitinating enzyme

KW - HAUSP

KW - Mdm2

KW - p53

KW - USP2a

U2 - doi:10.1038/sj.emboj.7601567

DO - doi:10.1038/sj.emboj.7601567

M3 - Article

SN - 0261-4189

VL - 26

SP - 976

EP - 986

JO - The EMBO Journal

JF - The EMBO Journal

IS - 4

ER -