The development of a combined electrical & mechanical stimulation bioreactor to improve tissue engineered muscle function

J.B. Vorstius, R.P. Keatch, K. Donnelly, P.S. Maher

    Research output: Chapter in Book/Report/Conference proceedingChapter

    2 Citations (Scopus)

    Abstract

    This paper describes the development of novel bioreactor systems for use in studying the development of tissue engineered muscle constructs. The bioreactor systems combine two environmental stimuli, mechanical loading and electrical pulses which, independently, are known to promote muscle tissue growth, into a single system to investigate whether further functional improvements can be achieved. The bioreactors are reprogrammable to enable different stimulation protocols to be assessed and allow the simultaneous stimulation of up to six tissues in a single system. This allows us to improve experimental throughput and speeds up our understanding of the physiological processes involved in skeletal muscle development.
    Original languageEnglish
    Title of host publicationIFMBE Proceedings
    Subtitle of host publicationWorld Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany.
    EditorsOlaf Dössel, Wolfgang C. Schlegel
    Place of PublicationBerlin & Heidelberg
    PublisherSpringer
    Pages126-129
    Number of pages4
    Volume25
    Edition10
    ISBN (Electronic)9783642039003
    ISBN (Print)9783642038990
    DOIs
    Publication statusPublished - 1 Jan 2009

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  • Cite this

    Vorstius, J. B., Keatch, R. P., Donnelly, K., & Maher, P. S. (2009). The development of a combined electrical & mechanical stimulation bioreactor to improve tissue engineered muscle function. In O. Dössel, & W. C. Schlegel (Eds.), IFMBE Proceedings: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany. (10 ed., Vol. 25, pp. 126-129). Springer . https://doi.org/10.1007/978-3-642-03900-3_37