The devil’s in the detail: cell-specific role of PPARγ in ILC2 activation by IL-33

Henry J. McSorley; J. Simon C. Arthur

doi:10.1038/s41385-020-00363-6

The devil’s in the detail: cell-specific role of PPARγ in ILC2 activation by IL-33

Henry J. McSorley (Lead / Corresponding author), J. Simon C. Arthur

Cell Signalling and Immunology

Research output: Contribution to journal › Comment/debate › peer-review

4 Citations (Scopus)

Abstract

PPARγ is a critical transcriptional regulator of adipogenesis and type 2 immune responses, however until recently its role in type 2 innate lymphoid cells had not been characterised. In two papers in this issue of Mucosal Immunology, PPARγ is shown to have a dominant role in ILC2 responses, mediating IL-33-responsiveness and activation.

Original language	English
Pages (from-to)	544-546
Number of pages	3
Journal	Mucosal Immunology
Volume	14
Early online date	16 Dec 2020
DOIs	https://doi.org/10.1038/s41385-020-00363-6
Publication status	Published - May 2021

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1038/s41385-020-00363-6

Cite this

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title = "The devil{\textquoteright}s in the detail: cell-specific role of PPARγ in ILC2 activation by IL-33",

abstract = "PPARγ is a critical transcriptional regulator of adipogenesis and type 2 immune responses, however until recently its role in type 2 innate lymphoid cells had not been characterised. In two papers in this issue of Mucosal Immunology, PPARγ is shown to have a dominant role in ILC2 responses, mediating IL-33-responsiveness and activation.",

author = "McSorley, {Henry J.} and Arthur, {J. Simon C.}",

note = "Funding Information: This work was supported by an MRC New Investigator Research Grant (MR/S000593/1—H.J.M.).",

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doi = "10.1038/s41385-020-00363-6",

language = "English",

volume = "14",

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journal = "Mucosal Immunology",

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AU - McSorley, Henry J.

AU - Arthur, J. Simon C.

N1 - Funding Information: This work was supported by an MRC New Investigator Research Grant (MR/S000593/1—H.J.M.).

PY - 2021/5

Y1 - 2021/5

N2 - PPARγ is a critical transcriptional regulator of adipogenesis and type 2 immune responses, however until recently its role in type 2 innate lymphoid cells had not been characterised. In two papers in this issue of Mucosal Immunology, PPARγ is shown to have a dominant role in ILC2 responses, mediating IL-33-responsiveness and activation.

AB - PPARγ is a critical transcriptional regulator of adipogenesis and type 2 immune responses, however until recently its role in type 2 innate lymphoid cells had not been characterised. In two papers in this issue of Mucosal Immunology, PPARγ is shown to have a dominant role in ILC2 responses, mediating IL-33-responsiveness and activation.

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U2 - 10.1038/s41385-020-00363-6

DO - 10.1038/s41385-020-00363-6

M3 - Comment/debate

C2 - 33328594

AN - SCOPUS:85097612007

SN - 1933-0219

VL - 14

SP - 544

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JO - Mucosal Immunology

JF - Mucosal Immunology

ER -

The devil’s in the detail: cell-specific role of PPARγ in ILC2 activation by IL-33

Abstract

ASJC Scopus subject areas

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MICA: Modulation of IL-33-dependent Responses Using Parasite Products (Transfer)

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The devil’s in the detail: cell-specific role of PPARγ in ILC2 activation by IL-33

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

MICA: Modulation of IL-33-dependent Responses Using Parasite Products (Transfer)

Cite this