The devil’s in the detail: cell-specific role of PPARγ in ILC2 activation by IL-33

TY - JOUR

T1 - The devil’s in the detail

T2 - cell-specific role of PPARγ in ILC2 activation by IL-33

AU - McSorley, Henry J.

AU - Arthur, J. Simon C.

N1 - Funding Information: This work was supported by an MRC New Investigator Research Grant (MR/S000593/1—H.J.M.).

PY - 2021/5

Y1 - 2021/5

N2 - PPARγ is a critical transcriptional regulator of adipogenesis and type 2 immune responses, however until recently its role in type 2 innate lymphoid cells had not been characterised. In two papers in this issue of Mucosal Immunology, PPARγ is shown to have a dominant role in ILC2 responses, mediating IL-33-responsiveness and activation.

AB - PPARγ is a critical transcriptional regulator of adipogenesis and type 2 immune responses, however until recently its role in type 2 innate lymphoid cells had not been characterised. In two papers in this issue of Mucosal Immunology, PPARγ is shown to have a dominant role in ILC2 responses, mediating IL-33-responsiveness and activation.

UR - https://www.scopus.com/pages/publications/85097612007

U2 - 10.1038/s41385-020-00363-6

DO - 10.1038/s41385-020-00363-6

M3 - Comment/debate

C2 - 33328594

AN - SCOPUS:85097612007

SN - 1933-0219

VL - 14

SP - 544

EP - 546

JO - Mucosal Immunology

JF - Mucosal Immunology

ER -