The Diffusible Signal Factor Family of Bacterial Cell-Cell Signals

J. Maxwell Dow (Lead / Corresponding author), Lynn M. Naughton, Birte Hollmann, Shi Qi An, Robert P. Ryan

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Bacterial cell-to-cell signals of the diffusible signal factor (DSF) family are cis-2-unsaturated fatty acids that differ in their chain length and branching patterns. Signaling involving DSF family members occurs in diverse bacteria to include plant and human pathogens. In the majority of these organisms, the perception of DSF is linked to turnover of the second messenger cyclic di-GMP by one of two "core" pathways. Additional "accessory" signal transduction pathways can also be found, but are not widely conserved. DSF signaling acts to regulate diverse functions to include biofilm formation and architecture, antibiotic resistance, and the production of virulence factors in pathogens. DSF family signals can also participate in interspecies signaling with other bacteria and interkingdom signaling with the yeast Candida albicans. Such interactions may have importance in modifying microbial behavior during polymicrobial infections.

Original languageEnglish
Pages (from-to)321-329
Number of pages9
JournalIsrael Journal of Chemistry
Issue number5
Early online date12 Feb 2016
Publication statusPublished - 23 May 2016


  • Bacterial virulence
  • Diffusible signal factors
  • Fatty acids
  • Regulation
  • Signal transduction

ASJC Scopus subject areas

  • Chemistry(all)


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