The diverse roles of protein kinase C in pancreatic β-cell function

Trevor J. Biden, Carsten Schmitz-Peiffer, James G. Burchfield, Ebru Gurisik, James Cantley, Christopher J. Mitchell, Lee Carpenter

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Members of the serine/threonine PKC (protein kinase C) family perform diverse functions in multiple cell types. All members of the family are activated in signalling cascades triggered by occupation of cell surface receptors, but the cPKC (conventional PKC) and nPKC (novel PKC) isoforms are also responsive to fatty acid metabolites. PKC isoforms are involved in various aspects of pancreatic β-cell function, including cell proliferation, differentiation and death, as well as regulation of secretion in response to glucose and muscarinic receptor agonists. Recently, the nPKC isoform, PKCε, has also been implicated in the loss of insulin secretory responsiveness that underpins the development of Type 2 diabetes.

Original languageEnglish
Pages (from-to)916-919
Number of pages4
JournalBiochemical Society Transactions
Volume36
Issue number5
DOIs
Publication statusPublished - Oct 2008

Keywords

  • Glucose-stimulated insulin secretion
  • Insulin secretion
  • Lipotoxicity
  • Pancreatic β-cell
  • Protein kinase C (PKC)
  • Type 2 diabetes

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  • Cite this

    Biden, T. J., Schmitz-Peiffer, C., Burchfield, J. G., Gurisik, E., Cantley, J., Mitchell, C. J., & Carpenter, L. (2008). The diverse roles of protein kinase C in pancreatic β-cell function. Biochemical Society Transactions, 36(5), 916-919. https://doi.org/10.1042/BST0360916