The diverse roles of protein kinase C in pancreatic β-cell function

Trevor J. Biden; Carsten Schmitz-Peiffer; James G. Burchfield; Ebru Gurisik; James Cantley; Christopher J. Mitchell; Lee Carpenter

doi:10.1042/BST0360916

The diverse roles of protein kinase C in pancreatic β-cell function

Trevor J. Biden, Carsten Schmitz-Peiffer, James G. Burchfield, Ebru Gurisik, James Cantley, Christopher J. Mitchell, Lee Carpenter

Systems Medicine

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Members of the serine/threonine PKC (protein kinase C) family perform diverse functions in multiple cell types. All members of the family are activated in signalling cascades triggered by occupation of cell surface receptors, but the cPKC (conventional PKC) and nPKC (novel PKC) isoforms are also responsive to fatty acid metabolites. PKC isoforms are involved in various aspects of pancreatic β-cell function, including cell proliferation, differentiation and death, as well as regulation of secretion in response to glucose and muscarinic receptor agonists. Recently, the nPKC isoform, PKCε, has also been implicated in the loss of insulin secretory responsiveness that underpins the development of Type 2 diabetes.

Original language	English
Pages (from-to)	916-919
Number of pages	4
Journal	Biochemical Society Transactions
Volume	36
Issue number	5
DOIs	https://doi.org/10.1042/BST0360916
Publication status	Published - Oct 2008

Keywords

Glucose-stimulated insulin secretion
Insulin secretion
Lipotoxicity
Pancreatic β-cell
Protein kinase C (PKC)
Type 2 diabetes

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10.1042/BST0360916

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