TY - JOUR
T1 - The diverse roles of protein kinase C in pancreatic β-cell function
AU - Biden, Trevor J.
AU - Schmitz-Peiffer, Carsten
AU - Burchfield, James G.
AU - Gurisik, Ebru
AU - Cantley, James
AU - Mitchell, Christopher J.
AU - Carpenter, Lee
PY - 2008/10
Y1 - 2008/10
N2 - Members of the serine/threonine PKC (protein kinase C) family perform diverse functions in multiple cell types. All members of the family are activated in signalling cascades triggered by occupation of cell surface receptors, but the cPKC (conventional PKC) and nPKC (novel PKC) isoforms are also responsive to fatty acid metabolites. PKC isoforms are involved in various aspects of pancreatic β-cell function, including cell proliferation, differentiation and death, as well as regulation of secretion in response to glucose and muscarinic receptor agonists. Recently, the nPKC isoform, PKCε, has also been implicated in the loss of insulin secretory responsiveness that underpins the development of Type 2 diabetes.
AB - Members of the serine/threonine PKC (protein kinase C) family perform diverse functions in multiple cell types. All members of the family are activated in signalling cascades triggered by occupation of cell surface receptors, but the cPKC (conventional PKC) and nPKC (novel PKC) isoforms are also responsive to fatty acid metabolites. PKC isoforms are involved in various aspects of pancreatic β-cell function, including cell proliferation, differentiation and death, as well as regulation of secretion in response to glucose and muscarinic receptor agonists. Recently, the nPKC isoform, PKCε, has also been implicated in the loss of insulin secretory responsiveness that underpins the development of Type 2 diabetes.
KW - Glucose-stimulated insulin secretion
KW - Insulin secretion
KW - Lipotoxicity
KW - Pancreatic β-cell
KW - Protein kinase C (PKC)
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=53849129913&partnerID=8YFLogxK
U2 - 10.1042/BST0360916
DO - 10.1042/BST0360916
M3 - Article
C2 - 18793161
AN - SCOPUS:53849129913
VL - 36
SP - 916
EP - 919
JO - Biochemical Society Transactions
JF - Biochemical Society Transactions
SN - 0300-5127
IS - 5
ER -