TY - JOUR
T1 - The double-edged sword of Notch signaling in cancer
AU - South, Andrew P.
AU - Cho, Raymond J.
AU - Aster, Jon C.
N1 - Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012
Y1 - 2012
N2 - Recent deep sequencing of cancer genomes has produced an explosion of new data implicating Notch signaling in several human cancers. Unlike most other pathways, these data indicate that Notch signaling can be either oncogenic or tumor suppressive, depending on the cellular context. In some instances, these relationships were predicted from mouse models or presaged by developmental roles for Notch, but in other cases were unanticipated. This review discusses the pathogenic and translational significance of these new findings.
AB - Recent deep sequencing of cancer genomes has produced an explosion of new data implicating Notch signaling in several human cancers. Unlike most other pathways, these data indicate that Notch signaling can be either oncogenic or tumor suppressive, depending on the cellular context. In some instances, these relationships were predicted from mouse models or presaged by developmental roles for Notch, but in other cases were unanticipated. This review discusses the pathogenic and translational significance of these new findings.
UR - http://www.scopus.com/inward/record.url?scp=84856766984&partnerID=8YFLogxK
U2 - 10.1016/j.semcdb.2012.01.017
DO - 10.1016/j.semcdb.2012.01.017
M3 - Review article
C2 - 22309843
SN - 1084-9521
JO - Seminars in Cell & Developmental Biology
JF - Seminars in Cell & Developmental Biology
ER -
