The druggable genome

Andrew L. Hopkins, Colin R. Groom

    Research output: Contribution to journalArticlepeer-review

    2379 Citations (Scopus)

    Abstract

    An assessment of the number of molecular targets that represent an opportunity for therapeutic intervention is crucial to the development of post-genomic research strategies within the pharmaceutical industry. Now that we know the size of the human genome, it is interesting to consider just how many molecular targets this opportunity represents. We start from the position that we understand the properties that are required for a good drug, and therefore must be able to understand what makes a good drug target.
    Original languageEnglish
    Pages (from-to)727-730
    Number of pages4
    JournalNature Reviews Drug Discovery
    Volume1
    Issue number9
    DOIs
    Publication statusPublished - Sep 2002

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