Projects per year
Protein O-GlcNAcylation is a reversible post-translational signalling modification of nucleocytoplasmic proteins that is essential for embryonic development in bilateria. In a search for a reductionist model to study O-GlcNAc signaling, we discovered the presence of functional O-GlcNAc transferase (OGT), O-GlcNAcase (OGA) and nucleocytoplasmic protein O-GlcNAcylation in the most basal extant animal, the placozoan Trichoplax adhaerens. We show via enzymatic characterization of Trichoplax OGT/OGA and genetic rescue experiments in Drosophila melanogaster that these proteins possess activities/functions similar to their bilaterian counterparts. The acquisition of O-GlcNAc signalling by metazoa may have facilitated the rapid and complex signalling mechanisms required for the evolution of multicellular organisms.
|Number of pages||14|
|Journal||Journal of Biological Chemistry|
|Early online date||16 Mar 2015|
|Publication status||Published - 8 May 2015|
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- 3 Finished
Aref#d: 21559. Molecular Mechanisms of Fungal Cell Wall Assembly (Programme Grant)
1/11/09 → 31/10/14
Aref#d: 21318. Molecular Mechanisms of O-GlcNAc Signalling (Senior Fellowship Renewal)
1/06/09 → 29/02/16