The effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model

Esin Tokmak Özşahin, Burcu Çam, Fahri Dere, Mehmet Kürkçü, Cüneyt Evrüke, Roger Soames, Özkan Oğuz (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Objectives: This study aims to investigate the effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model.

Materials and methods: Between May 2006 and July 2006, 60 female Wistar Albino rats aged three months were randomly allocated to three groups: sham operated receiving no treatment (Shm); ovariectomized-alendronate receiving 1 mg/kg/day alendronate sodium (Ovx-A), and ovariectomized-vehicle receiving 1 mL/kg/day physiological saline (Ovx-PS). Both Ovx groups received treatment through gastric gavage for 56 days.

Results: Densitometric measurements showed that bone mineral density decreased in the Ovx-PS and increased in Ovx-A groups (p<0.05). Biomechanical measurements showed a decrease in the breaking force in the Ovx-PS group and an increase in the Ovx-A group (p<0.05). Histomorphometric measurements showed that the Shm group had normal trabecular structure, while the Ovx-PS group had a less wellformed trabecular structure with a loss in the trabecular number and thickness and a corresponding increase in the trabecular spacing (p<0.05). In the Ovx-A group, there was an improvement in the trabecular structure with an increase in the trabecular number and thickness and a loss in the trabecular space (p<0.05).

Conclusion: Our study results suggest that alendronate sodium is a valuable treatment agent for osteoporosis in postmenopausal women.

Original languageEnglish
Pages (from-to)165-173
Number of pages9
JournalTurkish Journal of Physical Medicine and Rehabilitation
Volume63
Issue number2
DOIs
Publication statusPublished - Jun 2017

Keywords

  • Alendronate sodium
  • Biomechanics
  • Densitometry
  • Histomorphometry
  • Osteoporosis

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