The effect of angiotensin II and noradrenaline alone and in combination on renal sodium excretion in man

P. H. Seidelin, J. J. McMurray, R. A. Brown, A. D. Struthers

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    1. The renin-angiotensin-aldosterone-system is important for the maintenance of sodium balance in man. Recent animal evidence suggests the angiotensin II can modulate the effect of the renal sympathetic nervous system on renal function. We have investigated the possible interaction of physiological doses of angiotensin II and noradrenaline on sodium excretion in man. 2. Seven normal volunteers were studied on four occasions during maximum water diuresis sustained by oral hydration. Samples were obtained during a baseline and four subsequent 20 min periods (A-E). Placebo or noradrenaline was infused over periods B-E, and angiotensin II infused over period C. 3. There was no change in systemic blood pressure, heart rate or creatinine clearance caused by infusion of either angiotensin II, noradrenaline or both in combination. 4. Noradrenaline alone caused a significant fall in absolute and fractional sodium excretion. Angiotensin II when infused with placebo caused a 37% fall in absolute sodium excretion and a 32% fall when infused with noradrenaline (no significant difference between the 2 days). Similar changes were seen for urinary flow and fractional sodium excretion. 5. We have therefore found no evidence to support a postsynaptic interaction of low doses of angiotensin II and noradrenaline on renal sodium excretion in man.
    Original languageEnglish
    Pages (from-to)803-809
    Number of pages7
    JournalBritish Journal of Clinical Pharmacology
    Volume27
    Issue number6
    DOIs
    Publication statusPublished - 1989

    Fingerprint

    Angiotensin II
    Norepinephrine
    Sodium
    Placebos
    Kidney
    Diuresis
    Sympathetic Nervous System
    Renin-Angiotensin System
    Renal Elimination
    Creatinine
    Healthy Volunteers
    Heart Rate
    Maintenance
    Blood Pressure
    Water

    Cite this

    @article{fa51fc7fd53a4be3bfd11946fdaddc92,
    title = "The effect of angiotensin II and noradrenaline alone and in combination on renal sodium excretion in man",
    abstract = "1. The renin-angiotensin-aldosterone-system is important for the maintenance of sodium balance in man. Recent animal evidence suggests the angiotensin II can modulate the effect of the renal sympathetic nervous system on renal function. We have investigated the possible interaction of physiological doses of angiotensin II and noradrenaline on sodium excretion in man. 2. Seven normal volunteers were studied on four occasions during maximum water diuresis sustained by oral hydration. Samples were obtained during a baseline and four subsequent 20 min periods (A-E). Placebo or noradrenaline was infused over periods B-E, and angiotensin II infused over period C. 3. There was no change in systemic blood pressure, heart rate or creatinine clearance caused by infusion of either angiotensin II, noradrenaline or both in combination. 4. Noradrenaline alone caused a significant fall in absolute and fractional sodium excretion. Angiotensin II when infused with placebo caused a 37{\%} fall in absolute sodium excretion and a 32{\%} fall when infused with noradrenaline (no significant difference between the 2 days). Similar changes were seen for urinary flow and fractional sodium excretion. 5. We have therefore found no evidence to support a postsynaptic interaction of low doses of angiotensin II and noradrenaline on renal sodium excretion in man.",
    author = "Seidelin, {P. H.} and McMurray, {J. J.} and Brown, {R. A.} and Struthers, {A. D.}",
    year = "1989",
    doi = "10.1111/j.1365-2125.1989.tb03443.x",
    language = "English",
    volume = "27",
    pages = "803--809",
    journal = "British Journal of Clinical Pharmacology",
    issn = "0306-5251",
    publisher = "Wiley",
    number = "6",

    }

    The effect of angiotensin II and noradrenaline alone and in combination on renal sodium excretion in man. / Seidelin, P. H.; McMurray, J. J.; Brown, R. A.; Struthers, A. D.

    In: British Journal of Clinical Pharmacology, Vol. 27, No. 6, 1989, p. 803-809.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - The effect of angiotensin II and noradrenaline alone and in combination on renal sodium excretion in man

    AU - Seidelin, P. H.

    AU - McMurray, J. J.

    AU - Brown, R. A.

    AU - Struthers, A. D.

    PY - 1989

    Y1 - 1989

    N2 - 1. The renin-angiotensin-aldosterone-system is important for the maintenance of sodium balance in man. Recent animal evidence suggests the angiotensin II can modulate the effect of the renal sympathetic nervous system on renal function. We have investigated the possible interaction of physiological doses of angiotensin II and noradrenaline on sodium excretion in man. 2. Seven normal volunteers were studied on four occasions during maximum water diuresis sustained by oral hydration. Samples were obtained during a baseline and four subsequent 20 min periods (A-E). Placebo or noradrenaline was infused over periods B-E, and angiotensin II infused over period C. 3. There was no change in systemic blood pressure, heart rate or creatinine clearance caused by infusion of either angiotensin II, noradrenaline or both in combination. 4. Noradrenaline alone caused a significant fall in absolute and fractional sodium excretion. Angiotensin II when infused with placebo caused a 37% fall in absolute sodium excretion and a 32% fall when infused with noradrenaline (no significant difference between the 2 days). Similar changes were seen for urinary flow and fractional sodium excretion. 5. We have therefore found no evidence to support a postsynaptic interaction of low doses of angiotensin II and noradrenaline on renal sodium excretion in man.

    AB - 1. The renin-angiotensin-aldosterone-system is important for the maintenance of sodium balance in man. Recent animal evidence suggests the angiotensin II can modulate the effect of the renal sympathetic nervous system on renal function. We have investigated the possible interaction of physiological doses of angiotensin II and noradrenaline on sodium excretion in man. 2. Seven normal volunteers were studied on four occasions during maximum water diuresis sustained by oral hydration. Samples were obtained during a baseline and four subsequent 20 min periods (A-E). Placebo or noradrenaline was infused over periods B-E, and angiotensin II infused over period C. 3. There was no change in systemic blood pressure, heart rate or creatinine clearance caused by infusion of either angiotensin II, noradrenaline or both in combination. 4. Noradrenaline alone caused a significant fall in absolute and fractional sodium excretion. Angiotensin II when infused with placebo caused a 37% fall in absolute sodium excretion and a 32% fall when infused with noradrenaline (no significant difference between the 2 days). Similar changes were seen for urinary flow and fractional sodium excretion. 5. We have therefore found no evidence to support a postsynaptic interaction of low doses of angiotensin II and noradrenaline on renal sodium excretion in man.

    U2 - 10.1111/j.1365-2125.1989.tb03443.x

    DO - 10.1111/j.1365-2125.1989.tb03443.x

    M3 - Article

    VL - 27

    SP - 803

    EP - 809

    JO - British Journal of Clinical Pharmacology

    JF - British Journal of Clinical Pharmacology

    SN - 0306-5251

    IS - 6

    ER -