The effect of atrial natriuretic peptide on plasma renin activity, plasma aldosterone, and urinary dopamine in man

A. D. Struthers; J. V. Anderson; N. Payne; R. C. Causon; J. D. H. Slater; S. R. Bloom

doi:10.1007/BF00606663

The effect of atrial natriuretic peptide on plasma renin activity, plasma aldosterone, and urinary dopamine in man

A. D. Struthers
, J. V. Anderson
, N. Payne
, R. C. Causon
, J. D. H. Slater
, S. R. Bloom

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The acute natriuretic effect of human atrial natriuretic peptide (ANP) has been well described in man. We have now studied possible hormonal mediators of this effect. We studied six healthy volunteers on two occasions when they received either an infusion of ANP of 1.5 pmol X kg-1 X min-1 for 30 min followed by 15 pmol X kg-1 X min-1 for a further 30 min, or matching vehicle infusions in a randomized single-blind fashion. On the placebo day, plasma renin activity (PRA) rose from 1.26 +/- 0.08 to 1.57 +/- 0.14 ng A1 X ml-1 X h-1, while on the ANP study day PRA fell from 1.45 +/- 0.15 to 1.28 +/- 0.05 ng A1 X ml-1 X h-1 (p less than 0.01). No significant changes were found in plasma aldosterone concentrations or in urinary dopamine excretion. These results provide evidence that ANP suppresses renin release in man.

Original language	English
Pages (from-to)	223-226
Number of pages	4
Journal	European Journal of Clinical Pharmacology
Volume	31
Issue number	2
DOIs	https://doi.org/10.1007/BF00606663
Publication status	Published - 1986

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1007/BF00606663

Cite this

@article{a562b35785ac40c7a7907f856ea9b5c6,

title = "The effect of atrial natriuretic peptide on plasma renin activity, plasma aldosterone, and urinary dopamine in man",

abstract = "The acute natriuretic effect of human atrial natriuretic peptide (ANP) has been well described in man. We have now studied possible hormonal mediators of this effect. We studied six healthy volunteers on two occasions when they received either an infusion of ANP of 1.5 pmol X kg-1 X min-1 for 30 min followed by 15 pmol X kg-1 X min-1 for a further 30 min, or matching vehicle infusions in a randomized single-blind fashion. On the placebo day, plasma renin activity (PRA) rose from 1.26 +/- 0.08 to 1.57 +/- 0.14 ng A1 X ml-1 X h-1, while on the ANP study day PRA fell from 1.45 +/- 0.15 to 1.28 +/- 0.05 ng A1 X ml-1 X h-1 (p less than 0.01). No significant changes were found in plasma aldosterone concentrations or in urinary dopamine excretion. These results provide evidence that ANP suppresses renin release in man.",

author = "Struthers, \{A. D.\} and Anderson, \{J. V.\} and N. Payne and Causon, \{R. C.\} and Slater, \{J. D. H.\} and Bloom, \{S. R.\}",

year = "1986",

doi = "10.1007/BF00606663",

language = "English",

volume = "31",

pages = "223--226",

journal = "European Journal of Clinical Pharmacology",

issn = "0031-6970",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "2",

}

TY - JOUR

T1 - The effect of atrial natriuretic peptide on plasma renin activity, plasma aldosterone, and urinary dopamine in man

AU - Struthers, A. D.

AU - Anderson, J. V.

AU - Payne, N.

AU - Causon, R. C.

AU - Slater, J. D. H.

AU - Bloom, S. R.

PY - 1986

Y1 - 1986

N2 - The acute natriuretic effect of human atrial natriuretic peptide (ANP) has been well described in man. We have now studied possible hormonal mediators of this effect. We studied six healthy volunteers on two occasions when they received either an infusion of ANP of 1.5 pmol X kg-1 X min-1 for 30 min followed by 15 pmol X kg-1 X min-1 for a further 30 min, or matching vehicle infusions in a randomized single-blind fashion. On the placebo day, plasma renin activity (PRA) rose from 1.26 +/- 0.08 to 1.57 +/- 0.14 ng A1 X ml-1 X h-1, while on the ANP study day PRA fell from 1.45 +/- 0.15 to 1.28 +/- 0.05 ng A1 X ml-1 X h-1 (p less than 0.01). No significant changes were found in plasma aldosterone concentrations or in urinary dopamine excretion. These results provide evidence that ANP suppresses renin release in man.

AB - The acute natriuretic effect of human atrial natriuretic peptide (ANP) has been well described in man. We have now studied possible hormonal mediators of this effect. We studied six healthy volunteers on two occasions when they received either an infusion of ANP of 1.5 pmol X kg-1 X min-1 for 30 min followed by 15 pmol X kg-1 X min-1 for a further 30 min, or matching vehicle infusions in a randomized single-blind fashion. On the placebo day, plasma renin activity (PRA) rose from 1.26 +/- 0.08 to 1.57 +/- 0.14 ng A1 X ml-1 X h-1, while on the ANP study day PRA fell from 1.45 +/- 0.15 to 1.28 +/- 0.05 ng A1 X ml-1 X h-1 (p less than 0.01). No significant changes were found in plasma aldosterone concentrations or in urinary dopamine excretion. These results provide evidence that ANP suppresses renin release in man.

U2 - 10.1007/BF00606663

DO - 10.1007/BF00606663

M3 - Article

C2 - 2948826

SN - 0031-6970

VL - 31

SP - 223

EP - 226

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

IS - 2

ER -

The effect of atrial natriuretic peptide on plasma renin activity, plasma aldosterone, and urinary dopamine in man

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this