The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake

evidence from a case/control and a prospective study

Ron Do, Changchun Xie, Xiaohe Zhang, Satu Männistö, Kennet Harald, Shofiqul Islam, Swneke D. Bailey, Sumathy Rangarajan, Matthew J. McQueen, Rafael Diaz, Liu Lisheng, Xingyu Wang, Kaisa Silander, Leena Peltonen, Salim Yusuf, Veikko Salomaa, James C. Engert, Sonia S. Anand, INTERHEART investigators, Chim C. Lang

    Research output: Contribution to journalArticle

    62 Citations (Scopus)

    Abstract

    One of the most robust genetic associations for cardiovascular disease (CVD) is the Chromosome 9p21 region. However, the interaction of this locus with environmental factors has not been extensively explored. We investigated the association of 9p21 with myocardial infarction (MI) in individuals of different ethnicities, and tested for an interaction with environmental factors.
    Original languageEnglish
    Pages (from-to)e1001106
    JournalPLoS Medicine
    Volume8
    Issue number10
    DOIs
    Publication statusPublished - 2011

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    Cardiovascular Diseases
    Chromosomes
    Myocardial Infarction
    Prospective Studies

    Cite this

    Do, Ron ; Xie, Changchun ; Zhang, Xiaohe ; Männistö, Satu ; Harald, Kennet ; Islam, Shofiqul ; Bailey, Swneke D. ; Rangarajan, Sumathy ; McQueen, Matthew J. ; Diaz, Rafael ; Lisheng, Liu ; Wang, Xingyu ; Silander, Kaisa ; Peltonen, Leena ; Yusuf, Salim ; Salomaa, Veikko ; Engert, James C. ; Anand, Sonia S. ; INTERHEART investigators ; Lang, Chim C. / The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake : evidence from a case/control and a prospective study. In: PLoS Medicine. 2011 ; Vol. 8, No. 10. pp. e1001106.
    @article{c01afc9d274c457f87f0c8debdb8300d,
    title = "The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study",
    abstract = "One of the most robust genetic associations for cardiovascular disease (CVD) is the Chromosome 9p21 region. However, the interaction of this locus with environmental factors has not been extensively explored. We investigated the association of 9p21 with myocardial infarction (MI) in individuals of different ethnicities, and tested for an interaction with environmental factors.",
    author = "Ron Do and Changchun Xie and Xiaohe Zhang and Satu M{\"a}nnist{\"o} and Kennet Harald and Shofiqul Islam and Bailey, {Swneke D.} and Sumathy Rangarajan and McQueen, {Matthew J.} and Rafael Diaz and Liu Lisheng and Xingyu Wang and Kaisa Silander and Leena Peltonen and Salim Yusuf and Veikko Salomaa and Engert, {James C.} and Anand, {Sonia S.} and {INTERHEART investigators} and Lang, {Chim C.}",
    year = "2011",
    doi = "10.1371/journal.pmed.1001106",
    language = "English",
    volume = "8",
    pages = "e1001106",
    journal = "PLoS Medicine",
    issn = "1549-1277",
    publisher = "Public Library of Science",
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    }

    Do, R, Xie, C, Zhang, X, Männistö, S, Harald, K, Islam, S, Bailey, SD, Rangarajan, S, McQueen, MJ, Diaz, R, Lisheng, L, Wang, X, Silander, K, Peltonen, L, Yusuf, S, Salomaa, V, Engert, JC, Anand, SS, INTERHEART investigators & Lang, CC 2011, 'The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study', PLoS Medicine, vol. 8, no. 10, pp. e1001106. https://doi.org/10.1371/journal.pmed.1001106

    The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake : evidence from a case/control and a prospective study. / Do, Ron; Xie, Changchun; Zhang, Xiaohe; Männistö, Satu; Harald, Kennet; Islam, Shofiqul; Bailey, Swneke D.; Rangarajan, Sumathy; McQueen, Matthew J.; Diaz, Rafael; Lisheng, Liu; Wang, Xingyu; Silander, Kaisa; Peltonen, Leena; Yusuf, Salim; Salomaa, Veikko; Engert, James C.; Anand, Sonia S.; INTERHEART investigators ; Lang, Chim C.

    In: PLoS Medicine, Vol. 8, No. 10, 2011, p. e1001106.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake

    T2 - evidence from a case/control and a prospective study

    AU - Do, Ron

    AU - Xie, Changchun

    AU - Zhang, Xiaohe

    AU - Männistö, Satu

    AU - Harald, Kennet

    AU - Islam, Shofiqul

    AU - Bailey, Swneke D.

    AU - Rangarajan, Sumathy

    AU - McQueen, Matthew J.

    AU - Diaz, Rafael

    AU - Lisheng, Liu

    AU - Wang, Xingyu

    AU - Silander, Kaisa

    AU - Peltonen, Leena

    AU - Yusuf, Salim

    AU - Salomaa, Veikko

    AU - Engert, James C.

    AU - Anand, Sonia S.

    AU - INTERHEART investigators

    AU - Lang, Chim C.

    PY - 2011

    Y1 - 2011

    N2 - One of the most robust genetic associations for cardiovascular disease (CVD) is the Chromosome 9p21 region. However, the interaction of this locus with environmental factors has not been extensively explored. We investigated the association of 9p21 with myocardial infarction (MI) in individuals of different ethnicities, and tested for an interaction with environmental factors.

    AB - One of the most robust genetic associations for cardiovascular disease (CVD) is the Chromosome 9p21 region. However, the interaction of this locus with environmental factors has not been extensively explored. We investigated the association of 9p21 with myocardial infarction (MI) in individuals of different ethnicities, and tested for an interaction with environmental factors.

    U2 - 10.1371/journal.pmed.1001106

    DO - 10.1371/journal.pmed.1001106

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