The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study

Ron Do, Changchun Xie, Xiaohe Zhang, Satu Männistö, Kennet Harald, Shofiqul Islam, Swneke D. Bailey, Sumathy Rangarajan, Matthew J. McQueen, Rafael Diaz, Liu Lisheng, Xingyu Wang, Kaisa Silander, Leena Peltonen, Salim Yusuf, Veikko Salomaa, James C. Engert, Sonia S. Anand, INTERHEART investigators, Chim C. Lang

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    Abstract

    One of the most robust genetic associations for cardiovascular disease (CVD) is the Chromosome 9p21 region. However, the interaction of this locus with environmental factors has not been extensively explored. We investigated the association of 9p21 with myocardial infarction (MI) in individuals of different ethnicities, and tested for an interaction with environmental factors.
    Original languageEnglish
    Pages (from-to)e1001106
    JournalPLoS Medicine
    Volume8
    Issue number10
    DOIs
    Publication statusPublished - 2011

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  • Cite this

    Do, R., Xie, C., Zhang, X., Männistö, S., Harald, K., Islam, S., Bailey, S. D., Rangarajan, S., McQueen, M. J., Diaz, R., Lisheng, L., Wang, X., Silander, K., Peltonen, L., Yusuf, S., Salomaa, V., Engert, J. C., Anand, S. S., INTERHEART investigators, & Lang, C. C. (2011). The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study. PLoS Medicine, 8(10), e1001106. https://doi.org/10.1371/journal.pmed.1001106