The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study

Ron Do; Changchun Xie; Xiaohe Zhang; Satu Männistö; Kennet Harald; Shofiqul Islam; Swneke D. Bailey; Sumathy Rangarajan; Matthew J. McQueen; Rafael Diaz; Liu Lisheng; Xingyu Wang; Kaisa Silander; Leena Peltonen; Salim Yusuf; Veikko Salomaa; James C. Engert; Sonia S. Anand; INTERHEART investigators; Chim C. Lang

doi:10.1371/journal.pmed.1001106

The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study

Ron Do
, Changchun Xie
, Xiaohe Zhang
, Satu Männistö
, Kennet Harald
, Shofiqul Islam
, Swneke D. Bailey
, Sumathy Rangarajan
, Matthew J. McQueen
, Rafael Diaz
, Liu Lisheng
, Xingyu Wang
, Kaisa Silander
, Leena Peltonen
, Salim Yusuf
, Veikko Salomaa
, James C. Engert
, Sonia S. Anand
, INTERHEART investigators
, Chim C. Lang

Research output: Contribution to journal › Article › peer-review

89 Citations (Scopus)

Abstract

One of the most robust genetic associations for cardiovascular disease (CVD) is the Chromosome 9p21 region. However, the interaction of this locus with environmental factors has not been extensively explored. We investigated the association of 9p21 with myocardial infarction (MI) in individuals of different ethnicities, and tested for an interaction with environmental factors.

Original language	English
Pages (from-to)	e1001106
Journal	PLoS Medicine
Volume	8
Issue number	10
DOIs	https://doi.org/10.1371/journal.pmed.1001106
Publication status	Published - 2011

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SDG 3 Good Health and Well-being

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10.1371/journal.pmed.1001106

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Do, R., Xie, C., Zhang, X., Männistö, S., Harald, K., Islam, S., Bailey, S. D., Rangarajan, S., McQueen, M. J., Diaz, R., Lisheng, L., Wang, X., Silander, K., Peltonen, L., Yusuf, S., Salomaa, V., Engert, J. C., Anand, S. S., INTERHEART investigators, & Lang, C. C. (2011). The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study. PLoS Medicine, 8(10), e1001106. https://doi.org/10.1371/journal.pmed.1001106

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title = "The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study",

abstract = "One of the most robust genetic associations for cardiovascular disease (CVD) is the Chromosome 9p21 region. However, the interaction of this locus with environmental factors has not been extensively explored. We investigated the association of 9p21 with myocardial infarction (MI) in individuals of different ethnicities, and tested for an interaction with environmental factors.",

author = "Ron Do and Changchun Xie and Xiaohe Zhang and Satu M{\"a}nnist{\"o} and Kennet Harald and Shofiqul Islam and Bailey, \{Swneke D.\} and Sumathy Rangarajan and McQueen, \{Matthew J.\} and Rafael Diaz and Liu Lisheng and Xingyu Wang and Kaisa Silander and Leena Peltonen and Salim Yusuf and Veikko Salomaa and Engert, \{James C.\} and Anand, \{Sonia S.\} and \{INTERHEART investigators\} and Lang, \{Chim C.\}",

year = "2011",

doi = "10.1371/journal.pmed.1001106",

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volume = "8",

pages = "e1001106",

journal = "PLoS Medicine",

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Do, R, Xie, C, Zhang, X, Männistö, S, Harald, K, Islam, S, Bailey, SD, Rangarajan, S, McQueen, MJ, Diaz, R, Lisheng, L, Wang, X, Silander, K, Peltonen, L, Yusuf, S, Salomaa, V, Engert, JC, Anand, SS, INTERHEART investigators & Lang, CC 2011, 'The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study', PLoS Medicine, vol. 8, no. 10, pp. e1001106. https://doi.org/10.1371/journal.pmed.1001106

TY - JOUR

T1 - The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake

T2 - evidence from a case/control and a prospective study

AU - Do, Ron

AU - Xie, Changchun

AU - Zhang, Xiaohe

AU - Männistö, Satu

AU - Harald, Kennet

AU - Islam, Shofiqul

AU - Bailey, Swneke D.

AU - Rangarajan, Sumathy

AU - McQueen, Matthew J.

AU - Diaz, Rafael

AU - Lisheng, Liu

AU - Wang, Xingyu

AU - Silander, Kaisa

AU - Peltonen, Leena

AU - Yusuf, Salim

AU - Salomaa, Veikko

AU - Engert, James C.

AU - Anand, Sonia S.

AU - INTERHEART investigators

AU - Lang, Chim C.

PY - 2011

Y1 - 2011

N2 - One of the most robust genetic associations for cardiovascular disease (CVD) is the Chromosome 9p21 region. However, the interaction of this locus with environmental factors has not been extensively explored. We investigated the association of 9p21 with myocardial infarction (MI) in individuals of different ethnicities, and tested for an interaction with environmental factors.

AB - One of the most robust genetic associations for cardiovascular disease (CVD) is the Chromosome 9p21 region. However, the interaction of this locus with environmental factors has not been extensively explored. We investigated the association of 9p21 with myocardial infarction (MI) in individuals of different ethnicities, and tested for an interaction with environmental factors.

U2 - 10.1371/journal.pmed.1001106

DO - 10.1371/journal.pmed.1001106

M3 - Article

C2 - 22022235

SN - 1549-1676

VL - 8

SP - e1001106

JO - PLoS Medicine

JF - PLoS Medicine

IS - 10

ER -

The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study

Abstract

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