TY - JOUR
T1 - The effect of hip replacement on prescribing of NSAIDs, ulcer healing drugs and hospitalization - a matched cohort study
AU - Davey, Peter G.
AU - Mcmahon, Alex D.
AU - Barbone, Fabio
AU - Gillespie, William G.
AU - Rizvi, K. A.
AU - Macdonald, Thomas M.
PY - 1999/11/3
Y1 - 1999/11/3
N2 - Purpose. To assess the impact of total hip replacement on prescribing of non-steroidal anti-inflammatory drugs (NSAIDs), ulcer healing drugs (UHDs) and hospitalization. Methods. Observational matched cohort study. Results. There were 282 subjects in the hip replacement cohort and 1691 in the comparator cohort. Dispensing of NSAIDs fell from 89% to 57% after hip replacement but increased from 36% to 39% in comparators. Dispensing of UHDs fell from 33% to 30% after hip replacement but increased from 16% to 23% in the comparators. Hospitalization for upper gastrointestinal events fell from 2.5% to 1.8% after hip replacement but increased from 1.4% to 1.7% in comparators. Hospitalization for other causes increased from 32% to 42% after hip replacement compared with 25% to 28% in comparators. Conclusions. Hip replacement is associated with reduced prescribing of NSAIDs and UHDs. However, any effect on GI admissions will be small compared with increased hospitalization for other causes.
AB - Purpose. To assess the impact of total hip replacement on prescribing of non-steroidal anti-inflammatory drugs (NSAIDs), ulcer healing drugs (UHDs) and hospitalization. Methods. Observational matched cohort study. Results. There were 282 subjects in the hip replacement cohort and 1691 in the comparator cohort. Dispensing of NSAIDs fell from 89% to 57% after hip replacement but increased from 36% to 39% in comparators. Dispensing of UHDs fell from 33% to 30% after hip replacement but increased from 16% to 23% in the comparators. Hospitalization for upper gastrointestinal events fell from 2.5% to 1.8% after hip replacement but increased from 1.4% to 1.7% in comparators. Hospitalization for other causes increased from 32% to 42% after hip replacement compared with 25% to 28% in comparators. Conclusions. Hip replacement is associated with reduced prescribing of NSAIDs and UHDs. However, any effect on GI admissions will be small compared with increased hospitalization for other causes.
KW - Arthritis
KW - Gastrointestinal haemorrhage
KW - Hip replacement
KW - Non steroidal anti-inflammatory drugs (NSAIDs)
KW - Ulcer healing drugs
UR - http://www.scopus.com/inward/record.url?scp=0032703597&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1099-1557(199910/11)8:6<423::AID-PDS447>3.0.CO;2-T
DO - 10.1002/(SICI)1099-1557(199910/11)8:6<423::AID-PDS447>3.0.CO;2-T
M3 - Article
AN - SCOPUS:0032703597
SN - 1053-8569
VL - 8
SP - 423
EP - 431
JO - Pharmacoepidemiology and Drug Safety
JF - Pharmacoepidemiology and Drug Safety
IS - 6
ER -