The effect of hip replacement on prescribing of NSAIDs, ulcer healing drugs and hospitalization - a matched cohort study

Peter G. Davey (Lead / Corresponding author), Alex D. Mcmahon, Fabio Barbone, William G. Gillespie, K. A. Rizvi, Thomas M. Macdonald

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    Purpose. To assess the impact of total hip replacement on prescribing of non-steroidal anti-inflammatory drugs (NSAIDs), ulcer healing drugs (UHDs) and hospitalization. Methods. Observational matched cohort study. Results. There were 282 subjects in the hip replacement cohort and 1691 in the comparator cohort. Dispensing of NSAIDs fell from 89% to 57% after hip replacement but increased from 36% to 39% in comparators. Dispensing of UHDs fell from 33% to 30% after hip replacement but increased from 16% to 23% in the comparators. Hospitalization for upper gastrointestinal events fell from 2.5% to 1.8% after hip replacement but increased from 1.4% to 1.7% in comparators. Hospitalization for other causes increased from 32% to 42% after hip replacement compared with 25% to 28% in comparators. Conclusions. Hip replacement is associated with reduced prescribing of NSAIDs and UHDs. However, any effect on GI admissions will be small compared with increased hospitalization for other causes.

    Original languageEnglish
    Pages (from-to)423-431
    Number of pages9
    JournalPharmacoepidemiology and Drug Safety
    Volume8
    Issue number6
    DOIs
    Publication statusPublished - 3 Nov 1999

    Keywords

    • Arthritis
    • Gastrointestinal haemorrhage
    • Hip replacement
    • Non steroidal anti-inflammatory drugs (NSAIDs)
    • Ulcer healing drugs

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