Purpose. To assess the impact of total hip replacement on prescribing of non-steroidal anti-inflammatory drugs (NSAIDs), ulcer healing drugs (UHDs) and hospitalization. Methods. Observational matched cohort study. Results. There were 282 subjects in the hip replacement cohort and 1691 in the comparator cohort. Dispensing of NSAIDs fell from 89% to 57% after hip replacement but increased from 36% to 39% in comparators. Dispensing of UHDs fell from 33% to 30% after hip replacement but increased from 16% to 23% in the comparators. Hospitalization for upper gastrointestinal events fell from 2.5% to 1.8% after hip replacement but increased from 1.4% to 1.7% in comparators. Hospitalization for other causes increased from 32% to 42% after hip replacement compared with 25% to 28% in comparators. Conclusions. Hip replacement is associated with reduced prescribing of NSAIDs and UHDs. However, any effect on GI admissions will be small compared with increased hospitalization for other causes.
|Number of pages||9|
|Journal||Pharmacoepidemiology and Drug Safety|
|Publication status||Published - 3 Nov 1999|
- Gastrointestinal haemorrhage
- Hip replacement
- Non steroidal anti-inflammatory drugs (NSAIDs)
- Ulcer healing drugs