Atrial extracts have long been known to produce natriuresis but it is only recently that atrial natriuretic peptide (ANP) itself has been isolated, purified and sequenced. We have now developed a specific radio-immunoassay for ANP and assessed its biological activity by infusing ANP in normal volunteers. Low dose ANP infusion (1.5 pmol/kg per min) produced no haemodynamic or natriuretic effects. High dose ANP infusion (15 pmol/kg per min) produced an increase in plasma immunoreactive ANP levels of 203 +/- 78 pmol/l and caused the urinary sodium excretion to increase from 3.5 +/- 1.6 to 11.0 +/- 7.4 mmol/30 min period (P <0.05). No haemodynamic effects were seen with this high dose infusion. No changes in urinary dopamine were seen with either ANP infusion. This study shows that ANP is capable of producing a natriuresis in man in the absence of any generalized haemodynamic effects and that ANP may be an important modulator of salt and water balance in man.
|Journal||Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension|
|Publication status||Published - 1985|
Struthers, A. D., Anderson, J. V., Causon, R. C., Christofides, N. D., & Bloom, S. R. (1985). The effect of human atrial natriuretic peptide on urinary sodium and urinary dopamine excretion in man. Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension, 3(3), S315-S317.